Share This Author
The Role of Oxidative Stress
Detecting human coronary inflammation by imaging perivascular fat
It is revealed that inflamed human vessels exert paracrine effects on the surrounding PVAT, affecting local intracellular lipid accumulation in preadipocytes, which can be monitored using a CT imaging approach and has excellent sensitivity and specificity for detecting tissue inflammation.
Non-invasive detection of coronary inflammation using computed tomography and prediction of residual cardiovascular risk (the CRISP CT study): a post-hoc analysis of prospective outcome data
Obesity and cardiovascular disease: from pathophysiology to risk stratification.
The Role of Inflammation in Diabetes: Current Concepts and Future Perspectives
After an extensive review of the possible mechanisms that drive the metabolic pattern in T1D and T2D and the inflammatory pathways that are involved, it becomes ever clearer that future research should focus on a model of combined suppression for various inflammatory response pathways.
A novel machine learning-derived radiotranscriptomic signature of perivascular fat improves cardiac risk prediction using coronary CT angiography
The CCTA-based radiomic profiling of coronary artery PVAT detects perivascular structural remodelling associated with coronary artery disease, beyond inflammation and leads to a striking improvement of cardiac risk prediction over and above the current state-of-the-art.
The CD40/CD40 ligand system: linking inflammation with atherothrombosis.
Homocysteine and coronary atherosclerosis: from folate fortification to the recent clinical trials.
- C. Antoniades, A. Antonopoulos, D. Tousoulis, K. Marinou, C. Stefanadis
- BiologyEuropean heart journal
- 28 July 2008
A global approach of the molecular mechanisms relating Hcy with cardiovascular risk is provided and possible mechanistic explanations regarding the inability of clinical trials to detect any clinical benefit from Hcy-lowering treatment in secondary prevention are introduced.
Statins as Anti-Inflammatory Agents in Atherogenesis: Molecular Mechanisms and Lessons from the Recent Clinical Trials
- A. Antonopoulos, M. Margaritis, Regent Lee, K. Channon, C. Antoniades
- Biology, MedicineCurrent pharmaceutical design
- 31 March 2012
The molecular mechanisms responsible for the anti-inflammatory effects of statins, as well as clinical data on the non lipid-lowering, anti- inflammatory effects ofstatins on cardiovascular outcomes are described.
Adiponectin as a Link Between Type 2 Diabetes and Vascular NADPH Oxidase Activity in the Human Arterial Wall: The Regulatory Role of Perivascular Adipose Tissue
It is demonstrated for the first time in humans that reduced adiponectin levels in individuals with type 2 diabetes stimulates vascular NADPH oxidase, while PVAT “senses” the increased NAD PH oxidase activity in the underlying vessel and responds by upregulating adiponECTin gene expression.