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- Publications
- Influence
The Role of Oxidative Stress
- S. Tsalamandris, G. Vogiatzi, A. Antonopoulos, D. Tousoulis
- Biology
- 2018
Oxidative stress occurs due to the combination of excess reactive oxygen species and insufficient antioxidant capacity. Oxidative stress has been correlated with endothelial dysfunction, the… Expand
The CD40/CD40 ligand system: linking inflammation with atherothrombosis.
- C. Antoniades, C. Bakogiannis, D. Tousoulis, A. Antonopoulos, C. Stefanadis
- Medicine
- Journal of the American College of Cardiology
- 18 August 2009
The role of CD40/CD40 ligand (CD40L) in atherothrombosis is now widely accepted. However, the exact mechanisms linking the CD40/CD40L system and the soluble form of CD40 ligand (sCD40L) with… Expand
Obesity and cardiovascular disease: from pathophysiology to risk stratification.
- K. Marinou, D. Tousoulis, A. Antonopoulos, E. Stefanadi, C. Stefanadis
- Medicine
- International journal of cardiology
- 7 January 2010
Obesity is associated with numerous co-morbidities such as cardiovascular diseases (CVD), type 2 diabetes, hypertension and others. As obesity is considered to be a major risk factor for… Expand
Homocysteine and coronary atherosclerosis: from folate fortification to the recent clinical trials.
- C. Antoniades, A. Antonopoulos, D. Tousoulis, K. Marinou, C. Stefanadis
- Medicine
- European heart journal
- 28 July 2008
Plasma total homocysteine (Hcy) has been associated with cardiovascular risk in multiple large-scale epidemiological studies, and it has been considered as an independent risk factor for… Expand
Detecting human coronary inflammation by imaging perivascular fat
- A. Antonopoulos, F. Sanna, +23 authors C. Antoniades
- Medicine
- Science Translational Medicine
- 12 July 2017
Adipocyte size and lipid content in perivascular adipose tissue are inversely associated with coronary inflammation and atherosclerotic plaque burden in human patients. Picturing plaques and imaging… Expand
Non-invasive detection of coronary inflammation using computed tomography and prediction of residual cardiovascular risk (the CRISP CT study): a post-hoc analysis of prospective outcome data
- E. Oikonomou, M. Marwan, +18 authors C. Antoniades
- Medicine
- The Lancet
- 15 September 2018
Summary Background Coronary artery inflammation inhibits adipogenesis in adjacent perivascular fat. A novel imaging biomarker—the perivascular fat attenuation index (FAI)—captures coronary… Expand
Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: implications for endothelial function in…
- C. Antoniades, C. Shirodaria, +9 authors K. Channon
- Medicine
- European heart journal
- 1 May 2009
BACKGROUND
Asymmetrical dimethylarginine (ADMA), an endogenous inhibitor of endothelial nitric oxide synthase (eNOS), is considered to be a risk factor for atherosclerosis. However, the mechanisms… Expand
Statins as Anti-Inflammatory Agents in Atherogenesis: Molecular Mechanisms and Lessons from the Recent Clinical Trials
- A. Antonopoulos, M. Margaritis, R. Lee, K. Channon, C. Antoniades
- Medicine
- Current pharmaceutical design
- 31 March 2012
Ample evidence exists in support of the potent anti-inflammatory properties of statins. In cell studies and animal models statins exert beneficial cardiovascular effects. By inhibiting intracellular… Expand
Adiponectin as a Link Between Type 2 Diabetes and Vascular NADPH Oxidase Activity in the Human Arterial Wall: The Regulatory Role of Perivascular Adipose Tissue
- A. Antonopoulos, M. Margaritis, +17 authors C. Antoniades
- Biology, Medicine
- Diabetes
- 31 December 2014
Oxidative stress plays a critical role in the vascular complications of type 2 diabetes. We examined the effect of type 2 diabetes on NADPH oxidase in human vessels and explored the mechanisms of… Expand
Adiponectin: from obesity to cardiovascular disease
- C. Antoniades, A. Antonopoulos, D. Tousoulis, C. Stefanadis
- Medicine
- Obesity reviews : an official journal of the…
- 1 May 2009
Adiponectin is an adipokine whose biosynthesis is deranged in obesity and diabetes mellitus, predisposing to atherosclerosis. Evidence suggests that adiponectin has anti‐atherogenic properties by… Expand