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RETRACTED: Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children
BACKGROUND We investigated a consecutive series of children with chronic enterocolitis and regressive developmental disorder. METHODS 12 children (mean age 6 years [range 3-10], 11 boys) wereExpand
COX-1 and 2, intestinal integrity, and pathogenesis of nonsteroidal anti-inflammatory drug enteropathy in mice.
TLDR
COX-1 deficiency or inhibition and short-term COX-2 inhibition are compatible with normal small intestinal integrity and associated with significant intestinal pathology despite normal intestinal PGE(2) levels, suggesting a role for COx-2 in the maintenance of small intestine integrity in the mouse. Expand
Mucosal capillary thrombi in rectal biopsies
TLDR
Thrombi were observed in 8/13 cases of ulcerative colitis, 4/10 cases of Crohn's disease, 1/3 cases of unspecified inflammatory bowel disease and 5/20 cases of self‐limited colitis; the presence of capillary thrombi was not related to the severity of inflammation, but none of the control biopsies showed capillary Thrombi. Expand
Spontaneous Mucosal Lymphocyte Cytokine Profiles in Children with Autism and Gastrointestinal Symptoms: Mucosal Immune Activation and Reduced Counter Regulatory Interleukin-10
TLDR
There is a consistent profile of CD3+ lymphocyte cytokines in the small and large intestinal mucosa of these ASD children, involving increased pro-inflammatory and decreased regulatory activities. Expand
The concept of entero‐colonic encephalopathy, autism and opioid receptor ligands
TLDR
The gut–brain axis is central to certain encephalopathies of extra‐cranial origin, hepatic encephalopathy being the best characterized. Expand
Retraction of an interpretation
TLDR
Ten of the 12 original authors of the Early Report “Ileal-lymphoidnodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children”, published in The Lancet in 1998 are considering together formally retract the interpretation placed upon these findings in the paper. Expand
Enterocolitis in children with developmental disorders
TLDR
A new variant of inflammatory bowel disease is present in this group of children with developmental disorders, and scores of frequency and severity of inflammation were significantly greater in both affected children and those with UC, compared with controls. Expand
Colonic CD8 and gamma delta T-cell infiltration with epithelial damage in children with autism.
TLDR
Immunohistochemistry confirms a distinct lymphocytic colitis in autistic spectrum disorders in which the epithelium appears particularly affected, consistent with increasing evidence for gut epithelial dysfunction in autism. Expand
Intestinal Lymphocyte Populations in Children with Regressive Autism: Evidence for Extensive Mucosal Immunopathology
TLDR
The data provide further evidence of a pan-enteric mucosal immunopathology in children with regressive autism that is apparently distinct from other inflammatory bowel diseases. Expand
Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children (Retracted article. See vol 375, pg 445, 2010)
Background We investigated a consecutive series of children with chronic enterocolitis and regressive developmental disorder.Methods 12 children (mean age 6 years [range 3-10], 11 boys) were referredExpand
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