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The Endocrine Regulation of Aging by Insulin-like Signals
TLDR
Despite the similarities among mammals and invertebrates in insulin-like peptides and their signal cascade, more research is needed to determine whether these signals control aging in the same way in all the species by the same mechanism. Expand
C. elegans dauer formation and the molecular basis of plasticity.
TLDR
A molecular and genetic analysis of dauer formation has revealed key insights into how sensory and dietary cues are coupled to conserved endocrine pathways, including insulin/IGF, TGF-beta, serotonergic, and steroid hormone signal transduction, which govern the choice between reproduction and survival. Expand
The yeast secretory pathway is perturbed by mutations in PMR1, a member of a Ca2+ ATPase family
TLDR
Comparison of the deduced sequences of the PMR proteins with other known ion pumps showed that both proteins are very similar to Ca2+ ATPases, suggesting that PMR1 functions as a Ca2- pump affecting transit through the secretory pathway. Expand
The yeast Ca(2+)-ATPase homologue, PMR1, is required for normal Golgi function and localizes in a novel Golgi-like distribution.
TLDR
A global role for Ca2+ in the proper function of components governing transit and processing through the secretory pathway is implied, suggesting that Ca2- disposition is essential to normal Golgi function. Expand
A hormonal signaling pathway influencing C. elegans metabolism, reproductive development, and life span.
TLDR
It is shown that daf-9 acts downstream of these inputs but upstream of dAF-12, indicating that lipophilic hormones influence nematode metabolism, diapause, and life span. Expand
Identification of Ligands for DAF-12 that Govern Dauer Formation and Reproduction in C. elegans
TLDR
The first steroid hormones in nematodes are defined as ligands for an invertebrate orphan nuclear receptor and demonstrate that steroidal regulation of reproduction, from biology to molecular mechanism, is conserved from worms to humans. Expand
daf-12 encodes a nuclear receptor that regulates the dauer diapause and developmental age in C. elegans.
TLDR
It is proposed that DAF-12 integrates hormonal signals in cellular targets to coordinate major life history traits in Caenorhabditis elegans, and is expressed widely in target tissues from embryo to adult, but is upregulated during midlarval stages. Expand
daf-12 regulates developmental age and the dauer alternative in Caenorhabditis elegans.
TLDR
Novel daf-12 alleles are described that reveal a general role in advancing L3 stage programs and are proposed to provide cellular memories of chronological stage for selecting stage-appropriate developmental programs. Expand
A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling
TLDR
Dafachronic acid supplementation shortened the lifespan of long-lived daf-9 mutants and abolished their stress resistance, indicating that the ligand is “proaging” in response to signals from the dauer pathways, but extended the lifespan from germ-line ablated daf/cytochrome P450 mutants, showing that it is ‘antiaging’ in the germ- line longevity pathway. Expand
Hormonal control of C. elegans dauer formation and life span by a Rieske-like oxygenase.
TLDR
A conserved Rieske-like oxygenase, DAF-36, is identified as a component in hormone metabolism, implying that C. elegans hormone production has multiple steps and is distributed, and that it may provide one way that tissues register their current physiological state during organismal commitments. Expand
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