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Computational Fluid Dynamics Simulation of Airflow and Aerosol Deposition in Human Lungs
AbstractComputational fluid dynamics (CFD) simulations of airflow and particle deposition in geometries representing the human tracheobronchial tree were conducted. Two geometries were used in thisExpand
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Imaging nanoprobe for prediction of outcome of nanoparticle chemotherapy by using mammography.
PURPOSE To prospectively predict the effectiveness of a clinically used nanochemotherapeutic agent by detecting and measuring the intratumoral uptake of an x-ray contrast agent nanoprobe by usingExpand
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Controlled targeting of liposomal doxorubicin via the folate receptor in vitro.
Differential expression of folate receptor has been exploited to target liposomes to tumors. Astrogliomas express low folate receptor levels and are typically surrounded by normal cells expressingExpand
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A dual-ligand approach for enhancing targeting selectivity of therapeutic nanocarriers.
Conjugation of ligands to nano-scale drug carriers targeting over-expressed cell surface receptors is a promising approach for delivery of therapeutic agents to tumor cells. However, most commonlyExpand
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Long-residence-time nano-scale liposomal iohexol for X-ray-based blood pool imaging.
RATIONALE AND OBJECTIVES Although soluble nonionic iodine compounds with low systemic toxic effects have been developed for use in computed tomography (CT), they have short residence times of a fewExpand
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New Dual Mode Gadolinium Nanoparticle Contrast Agent for Magnetic Resonance Imaging
Background Liposomal-based gadolinium (Gd) nanoparticles have elicited significant interest for use as blood pool and molecular magnetic resonance imaging (MRI) contrast agents. Previous generationsExpand
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Thioaptamer Conjugated Liposomes for Tumor Vasculature Targeting
Recent developments in multi-functional nanoparticles offer a great potential for targeted delivery of therapeutic compounds and imaging contrast agents to specific cell types, in turn, enhancingExpand
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Hypoxia-induced autophagic response is associated with aggressive phenotype and elevated incidence of metastasis in orthotopic immunocompetent murine models of head and neck squamous cell carcinomas
Hypoxia confers resistance to chemoradiation therapy and promotes metastasis in head and neck squamous cell carcinomas (HNSCC). We investigated the effects of hypoxia in tumor phenotype usingExpand
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Indocyanine green fluorescence in second near-infrared (NIR-II) window
Indocyanine green (ICG), a FDA approved near infrared (NIR) fluorescent agent, is used in the clinic for a variety of applications including lymphangiography, intra-operative lymph nodeExpand
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Intravenous Delivery of Targeted Liposomes to Amyloid-β Pathology in APP/PSEN1 Transgenic Mice
Extracellular amyloid-β (Aβ) plaques and intracellular neurofibrillary tangles constitute the major neuropathological hallmarks of Alzheimer’s disease (AD). It is now apparent that parenchymal AβExpand
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