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Guidelines for diagnosis and therapy of MEN type 1 and type 2.
TLDR
The specific RET codon mutation correlates with the MEN2 syndromic variant, the age of onset of M TC, and the aggressiveness of MTC; consequently, that mutation should guide major management decisions, such as whether and when to perform thyroidectomy.
A survey on adrenal incidentaloma in Italy. Study Group on Adrenal Tumors of the Italian Society of Endocrinology.
TLDR
Results indicate that mass size is the most reliable variable in separating benign from malignant AI and Adrenalectomy should be recommended for AI greater than 4.0 cm because of the increased risk of malignancy, especially in young patients.
Diagnosis and complications of Cushing's syndrome: a consensus statement.
TLDR
The consensus statement on diagnostic criteria and the diagnosis and treatment of complications of this syndrome reached at the workshop is hereby summarized.
A Survey on Adrenal Incidentaloma in Italy
TLDR
A national survey on occasionally discovered adrenal masses under the auspices of the Italian Society of Endocrinology, which includes 1096 cases collected in 26 centers between 1980 and 1995, concluded that 85% of the masses were nonhypersecretory and 9.2% were defined as subclinical Cushing’s syndrome.
Etoposide, doxorubicin and cisplatin plus mitotane in the treatment of advanced adrenocortical carcinoma: a large prospective phase II trial.
TLDR
Overall survival of patients attaining a disease free status (clinical complete responders+radically resected) was significantly higher than that of patients with partial response or no response (P<0.002), androgen secretion was associated with long survival, while glucocorticoid secretion wasassociated with poor prognosis both in univariate and multivariate analysis.
Glucocorticoid-induced osteoporosis: an update
CONSENSUS: Guidelines for Diagnosis and Therapy of MEN Type 1 and Type 2
TLDR
The specific RET codon mutation correlates with the MEN2 syndromic variant, the age of onset of M TC, and the aggressiveness of MTC; consequently, that mutation should guide major management decisions, such as whether and when to perform thyroidectomy.
Prevalence of adrenal incidentaloma in a contemporary computerized tomography series
TLDR
It is confirmed that subjects undergoing computerized tomography scan of the chest in a screening program of lung cancer in Piedmont are presently able to identify incidentally discovered adrenal masses more often than in early years and that the prevalence of adrenal incidentalomas on CT images is approaching that of autopsy series.
Adrenal incidentaloma: a new cause of the metabolic syndrome?
TLDR
Many patients with incidental adrenal adenoma display altered glucose tolerance, that may be explained by reduced insulin sensitivity, and increased blood pressure levels in comparison with carefully age- and BMI-matched controls.
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