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Correlates and Predictors of Adherence to Highly Active Antiretroviral Therapy: Overview of Published Literature
This review summarizes the results of 20 studies investigating the issue of barriers to optimal highly active antiretroviral therapy (HAART) adherence and found inconsistent findings regarding the relationship of adherence.
Sexual Activity Without Condoms and Risk of HIV Transmission in Serodifferent Couples When the HIV-Positive Partner Is Using Suppressive Antiretroviral Therapy.
Evaluating the rate of within-couple HIV transmission among serodifferent heterosexual and MSM couples during periods of sex without condoms and when the HIV-positive partner had HIV-1 RNA load less than 200 copies/mL found no phylogenetically linked transmissions.
Self‐Reported Symptoms and Medication Side Effects Influence Adherence to Highly Active Antiretroviral Therapy in Persons With HIV Infection
In addition to patient characteristics, medication‐related variables, and reasons for nonadherence, patient‐reported symptoms and medication side effects were significantly associated with adherence to HAART.
Depressive symptoms, neurocognitive impairment, and adherence to highly active antiretroviral therapy among HIV-infected persons.
The association of depressive symptoms, neurocognitive impairment, and adherence to highly active antiretroviral therapy (HAART) was evaluated in 135 HIV-infected persons. Thirty percent reported
Depression Is a Risk Factor for Suboptimal Adherence to Highly Active Antiretroviral Therapy
Early recognition and proper management of depressive comorbidity could be an effective intervention strategy to improve adherence and may make a difference in the quality of life, social functioning, and disease course of people with HIV.
Minimally invasive diagnosis of acquired immunodeficiency syndrome-related primary central nervous system lymphoma.
The presence of EBV-DNA in lumbar CSF is a sensitive and highly specific diagnostic marker of AIDS-PCNSL, and EBV -DNA detection in this fluid may allow a minimally invasive diagnosis in a large percentage of patients with brain lymphomas.
AIDS-related focal brain lesions in the era of highly active antiretroviral therapy
During the HAART era, AIDS-related primary CNS lymphoma showed a strong decline, toxoplasmic encephalitis remained stable, and progressive multifocal leukoencephalopathy showed a slight increase, and focal white matter lesions without mass effect or contrast enhancement became the most frequently seen focal brain lesion.
Value of combined approach with thallium-201 single-photon emission computed tomography and Epstein-Barr virus DNA polymerase chain reaction in CSF for the diagnosis of AIDS-related primary CNS
Because PCNSL likelihood is extremely high in patients with hyperactive lesions and positive EBV-DNA, brain biopsy could be avoided, and patients could promptly undergo radiotherapy or multimodal therapy.
Evaluation of cerebrospinal fluid EBV‐DNA and IL‐10 as markers for in vivo diagnosis of AIDS‐related primary central nervous system lymphoma
AIDS lymphomas show an enhanced production of IL‐10 which is generally associated with the presence of EBV in lymphoma cells, and EBV‐DNA in cerebrospinal fluid has been indicated as a useful tumour marker for this HIV‐related neoplasm.