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Cardiac and renal protective effects of dexmedetomidine in cardiac surgeries: A randomized controlled trial
TLDR
Dexmedetomidine reduced cardiac and renal injury as evidenced by lower concentration of myocardial-specific proteins, kidney-specific urinary proteins, and pro-inflammatory cytokines, and it caused higher creatinine clearance and lower serum cystatin C. Expand
Comparison of suxamethonium and different combinations of rocuronium and mivacurium for rapid tracheal intubation in children.
TLDR
This study demonstrated that the combination of rocuronium 0.45 mg kg-1 and mivacurium0.15 mgkg-1 could possibly be considered as an acceptable alternative to suxamethonium when rapid sequence induction of anaesthesia is indicated in children because it provides uniform excellent intubating conditions and complete neuromuscular block in < 60 s. Expand
A comparison of sugammadex and neostigmine for reversal of rocuronium‐induced neuromuscular blockade in children
TLDR
The current trial was aimed to compare between sugammadex and neostigmine concerning the recovery time from neuromuscular blockade and it was hypothesised that sugamadex might have shorter recovery time than neostIGmine. Expand
Comparative Clinical Pharmacology of Rocuronium, Cisatracurium, and Their Combination
TLDR
Cisatracurium is four to five times more potent than rocuronium and roCuronium had a faster onset, and a faster spontaneous T1 and train‐of‐four recovery times that were significant except at maximum recovery with the 2xED95 dose. Expand
Comparative effect of propofol versus sevoflurane on renal ischemia/reperfusion injury after elective open abdominal aortic aneurysm repair
TLDR
Postoperative urinary concentrations of all measured kidney specific proteins and serum pro-inflammatory cytokines were significantly lower in the propofol group compared with the sevoflurane group and this could have clinical implications in situations of expected renal I/R injury. Expand
A randomised controlled trial comparing the effects of propofol with isoflurane in patients with diastolic dysfunction undergoing coronary artery bypass graft surgery
TLDR
Both propofol and isoflurane improved left ventricular diastolic function as evidenced by significant increases in E/A ratios, and significant decreases in deceleration time and isovolumetric relaxation time; the improvement was greater in the isofLurane group. Expand
Comparative clinical pharmacology of rocuronium, cisatracurium, and their combination.
TLDR
Cisatracurium is four to five times more potent than roCuronium and rocuronium had a faster onset, and a faster spontaneous T1 and train-of-four recovery times that were significant except at maximum recovery with the 2xED95 dose. Expand
Effect of N‐acetylcysteine on cardiac injury and oxidative stress after abdominal aortic aneurysm repair: A randomized controlled trial
TLDR
Assessment of the efficacy of NAC for cardiac protection in patients undergoing elective abdominal aortic aneurysm repair and the antioxidant properties of N‐acetylcysteine are evaluated. Expand
Enzymatic Antagonism of Mivacurium-induced Neuromuscular Blockade by Human Plasma Cholinesterase
TLDR
This study was designed to establish dose-response relationships for PCHE as an antagonist of mivacurium-induced neuromuscular blockade. Expand
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