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Cell fusion induced by ERVWE1 or measles virus causes cellular senescence.
Fusion-inducedsenescence might be needed for proper syncytiotrophoblast function during embryonic development, and reuse of this senescence program later in life protects against pathological expression of endogenous fusogens and fusogenic viral infections. Expand
Acrocentric centromere organization within the chromocenter of the human sperm nucleus
- M. Gurevitch, A. Amiel, M. Ben-Zion, M. Fejgin, B. Bartoov
- Biology, Medicine
- Molecular reproduction and development
- 1 December 2001
It is concluded that in human sperm nuclei, the acrocentric centromeres are organized within a nonlocalized structural element in the chromocenter, which has important implications for nuclear function (rRNA) that is not directly related to sperm cell function or early embryo development. Expand
Short telomeres may play a role in placental dysfunction in preeclampsia and intrauterine growth restriction.
- T. Biron-Shental, R. Sukenik-Halevy, +4 authors A. Amiel
- American journal of obstetrics and gynecology
- 1 December 2009
Telomeres are shorter in placentas from preeclampsia and intrauterine growth restriction pregnancies, implies different placental stress-related mechanisms in preeclampia with or without intrauterines growth restriction. Expand
Complete hydatidiform mole and a coexistent viable fetus: report of two cases and review of the literature.
Complete hydatidiform mole and coexistent fetus is a rare occurrence and is associated with an increased risk of persistent gestational trophoblastic tumor and it seems that in the presence of a stable pregnancy, normal karyotype, and a normal sonogram it is reasonable to allow the pregnancy to continue. Expand
Bcl-2 rearrangement in patients with chronic hepatitis C associated with essential mixed cryoglobulinemia type II.
The JH/bcl-2 translocation may constitute a pathogenetic link for the development of NHL in patients with HCV infection. Expand
Wiedemann-Beckwith syndrome: further prenatal characterization of the condition.
- O. Reish, I. Lerer, +4 authors D. Abeliovich
- Biology, Medicine
- American journal of medical genetics
- 22 January 2002
The anomalies that might be detected prenatally by ultrasound and that may suggest the syndrome are tabulated and PCR amplification of polymorphic loci mapping to 11p15.5 region is recommended to detect possible maternal deletions or inversions, paternal duplications, and UPD that may account for the largest subset of sporadic WBS reaching 25% of cases. Expand
TERC telomerase subunit gene copy number in placentas from pregnancies complicated with intrauterine growth restriction.
- T. Biron-Shental, D. Kidron, +4 authors A. Amiel
- Biology, Chemistry
- Early human development
- 1 February 2011
The results support the observations of telomere shortening and decreased telomerase activity in IUGR placentas and suggest that these findings might play a role in the pathophysiology of IugR, perhaps by promoting senescence in trophoblasts of IUGr placenta. Expand
Is isolated palatal anomaly an indication to screen for 22q11 region deletion?
- O. Reish, Y. Finkelstein, +4 authors A. Amiel
- The Cleft palate-craniofacial journal : official…
- 1 March 2003
A routine screening for the 22q11 deletion in older children and adults presenting with an isolated palatal anomaly may not be required and other signs related to VCFS such as facial dysmorphism and behavioral or psychiatric disorders may evolve at an older age. Expand
Clinical detection of BCR-abl fusion by in situ hybridization in chronic myelogenous leukemia.
We describe the use of the fluorescence in situ hybridization (FISH) technique to detect residual Philadelphia chromosome-positive (Ph+) cells in a patient with blastic phase chronic myelogenous… Expand
Monoclonal lymphocyte proliferation and bcl‐2 rearrangement in essential mixed cryoglobulinaemia
- M. Ellis, M. Rathaus, A. Amiel, Y. Manor, A. Klein, M. Lishner
- Biology, Medicine
- European journal of clinical investigation
- 1 November 1995
Abstract. A patient with essential mixed cryoglobulinaemia (EMC) type II and hepatitis C virus (HCV) infection, in whom immunophenotypic and genotypic studies demonstrated a clonal proliferation of B… Expand