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Fungal endophytes: unique plant inhabitants with great promises
- A. Aly, A. Debbab, P. Proksch
- Biology, Environmental ScienceApplied Microbiology and Biotechnology
- 27 April 2011
The chemical potential of endophytic fungi for drug discovery will be discussed with focus on the detection of pharmaceutically valuable plant constituents as products of fungal biosynthesis.
Cytotoxic metabolites from the fungal endophyte Alternaria sp. and their subsequent detection in its host plant Polygonum senegalense.
From the Egyptian medicinal plant Polygonum senegalense the fungal endophyte Alternaria sp. was isolated. Extracts of the fungus grown either in liquid culture or on solid rice media exhibited…
Fungal endophytes from higher plants: a prolific source of phytochemicals and other bioactive natural products
This overview will highlight the chemical potential of endophytic fungi with focus on the detection of pharmaceutically valuable plant constituents, e.g. paclitaxel, camptothecin and podophyllotoxin, as products of fungal biosynthesis, and new bioactive metabolites reported in recent years from fungal endophytes of terrestrial and mangrove plants.
Methods for isolation of marine-derived endophytic fungi and their bioactive secondary products
This protocol gives a detailed description of methods useful for the isolation and cultivation of fungi associated with various marine organisms for the extraction, characterization and structure elucidation of biologically active secondary metabolites produced by these marine-derived endophytic fungi.
Co-Cultivation—A Powerful Emerging Tool for Enhancing the Chemical Diversity of Microorganisms
This review highlights the power of co-cultivation for increasing the chemical diversity of bacteria and fungi drawing on published studies from the marine and from the terrestrial habitat alike.
Bioactive Compounds from Marine Bacteria and Fungi
- A. Debbab, A. Aly, Wenhan Lin, P. Proksch
- Environmental Science, BiologyMicrobial biotechnology
- 19 August 2010
This review covers new biologically active natural products published recently and highlights the chemical potential of marine microorganisms, with focus on bioactive products as well as on their mechanisms of action.
Fifty years of drug discovery from fungi
Given that estimations of fungal biodiversity exceed by far the number of already identified species, chances to find hitherto unidentified fungal species and novel bioactive fungal products are still high, further compounds with medicinal or agricultural potential from less investigated fungal taxa can be expected in the years to come.
Bioactive metabolites from the endophytic fungus Ampelomyces sp. isolated from the medicinal plant Urospermum picroides.
Bioactive metabolites from the endophytic fungus Stemphylium globuliferum isolated from Mentha pulegium.
The endophytic fungus Stemphylium globuliferum was isolated from stem tissues of the Moroccan medicinal plant Mentha pulegium, and extracts of the fungus exhibited considerable cytotoxicity when tested in vitro against L5178Y cells.
Endophytes and associated marine derived fungi—ecological and chemical perspectives
New insights into fungal-host interaction, chemical communication, and chemo-ecological roles of fungal metabolites, as well as new strategies for bioprospecting are presented.