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Snake venomics of the lancehead pitviper Bothrops asper: geographic, individual, and ontogenetic variations.
TLDR
This study represents the first detailed characterization of individual and ontogenetic venom protein profile variations in two geographical isolated B. asper populations, and highlights the necessity of using pooled venoms as a statistically representative venom for antivenom production.
Snake venomics of the Central American rattlesnake Crotalus simus and the South American Crotalus durissus complex points to neurotoxicity as an adaptive paedomorphic trend along Crotalus dispersal
TLDR
The increased concentration of the neurotoxins crotoxin and crotamine in South American rattlesnake venoms strongly argues that the gain of neurotoxicity and lethal venom activities to mammals may have represented the key axis along which overall venom toxicity has evolved during Crotalus durissus invasion of South America.
Snake venomics and antivenomics: Proteomic tools in the design and control of antivenoms for the treatment of snakebite envenoming.
TLDR
Several aspects of antivenom manufacture and control are discussed in which the proteomic analysis of snake venoms, for which the term 'snake venomics' has been coined, might play a relevant supporting role.
Snake venomics and antivenomics of Bothrops colombiensis, a medically important pitviper of the Bothrops atrox-asper complex endemic to Venezuela: Contributing to its taxonomy and snakebite
TLDR
The virtually indistinguishable immunological crossreactivity of a Venezuelan ABC antiserum and the Costa Rican ICP polyvalent antivenom towards the venoms of B. colombiensis and B. asper suggests the possibility of indistinctly using these antivenoms for the management of snakebites by any of these Bothrops species.
Venomic and antivenomic analyses of the Central American coral snake, Micrurus nigrocinctus (Elapidae).
TLDR
The proteome of the venom of Micrurus nigrocinctus (Central American coral snake) was analyzed by a "venomics" approach, revealing a complex protein composition that mainly exert myotoxicity.
The NanI and NanJ Sialidases of Clostridium perfringens Are Not Essential for Virulence
TLDR
Cytotoxicity assays showed that supernatants containing NanI or overexpressing NanJ enhanced alpha-toxin-mediated cytotoxicity, providing evidence that neither the NanI sIALidase nor the NanJ sialidase is essential for virulence.
Bacterial Sphingomyelinases and Phospholipases as Virulence Factors
TLDR
The identification of sphingomyelinases and phospholipases important for bacterial pathogenesis and the development of inhibitors for these enzymes could generate candidate vaccines and therapeutic agents, which will diminish the impacts of the associated human and animal diseases.
A Cellular Deficiency of Gangliosides Causes Hypersensitivity to Clostridium perfringens Phospholipase C*
TLDR
It is demonstrated that a reduction in gangliosides renders cells more susceptible to the membrane damage caused by Cp-PLC and revealed a previously unrecognized synergism between Cp PLC and C. perfringens sialidase, providing new insights toward understanding the pathogenesis of clostridial myonecrosis.
Ocatin. A Novel Tuber Storage Protein from the Andean Tuber Crop Oca with Antibacterial and Antifungal Activities1
TLDR
The findings suggest that an ancient scaffolding protein was recruited in the oca tuber to serve a storage function and that proteins from the Betv 1/PR-10/MLP family might play a role in natural resistance to pathogens.
Venoms of Micrurus coral snakes: Evolutionary trends in compositional patterns emerging from proteomic analyses.
TLDR
Results gathered to date reveal a dichotomy of venom phenotypes regarding the relative abundance of the omnipresent phospholipases A2 and 'three-finger' toxins within Micrurus, and two divergent toxin expression phenotypes appear to be related to phylogenetic positions and geographical distributions along a North-South axis in the Americas.
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