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Nuclear pore components are involved in the transcriptional regulation of dosage compensation in Drosophila.
The purification of enzymatically active MSL complexes from Drosophila embryos, Schneider cells, and human HeLa cells reveals an unexpected physical and functional connection between nuclear pore components and chromatin regulation through MSL proteins, highlighting the role of nucleoporins in gene regulation in higher eukaryotes. Expand
Activation of transcription through histone H4 acetylation by MOF, an acetyltransferase essential for dosage compensation in Drosophila.
It is demonstrated that MOF, a protein required for dosage compensation with significant sequence similarity to the MYST family of acetyl transferases, is a histone acetyltransferase that acetylates chromatin specifically at histone H4 lysine 16. Expand
High-resolution TADs reveal DNA sequences underlying genome organization in flies
Software to identify high-resolution TAD boundaries and reveal their relationship to underlying DNA motifs is developed and it is demonstrated that boundaries can be accurately predicted using only the motif sequences at open chromatin sites. Expand
hMOF Histone Acetyltransferase Is Required for Histone H4 Lysine 16 Acetylation in Mammalian Cells
- M. Taipale, S. Rea, +4 authors A. Akhtar
- Biology, Medicine
- Molecular and Cellular Biology
- 1 August 2005
The data show that h MOF is required for histone H4 lysine 16 acetylation in mammalian cells and suggest that hMOF has a role in DNA damage response during cell cycle progression, which is similar to the Drosophila dosage compensation system. Expand
Nuclear Pore Proteins Nup153 and Megator Define Transcriptionally Active Regions in the Drosophila Genome
- J. M. Vaquerizas, Ritsuko Suyama, Jop Kind, K. Miura, N. Luscombe, A. Akhtar
- Biology, Medicine
- PLoS genetics
- 1 February 2010
Nucleoporins are established as a major class of global regulators for gene expression in Drosophila melanogaster and it is suggested that NAR–binding is used for chromosomal organization that enables gene expression control. Expand
Dosage compensation in Drosophila melanogaster: epigenetic fine-tuning of chromosome-wide transcription
This Review highlights the known facts and open questions of dosage compensation in D. melanogaster and investigates the intriguing interplay between multiple levels of local and long-range chromatin regulation required for the fine-tuned transcriptional activation of a heterogeneous gene population. Expand
The nonspecific lethal complex is a transcriptional regulator in Drosophila.
The biochemical characterization of the nonspecific lethal (NSL) complex that associates with the histone acetyltransferase MOF in both Drosophila and mammals concludes that the NSL complex acts as a major transcriptional regulator in Drosophile. Expand
The nuclear envelope and transcriptional control
Cells have evolved sophisticated multi-protein complexes that can regulate gene activity at various steps of the transcription process, and nuclear-pore components seem to not only recruit the RNA-processing and RNA-export machinery, but contribute a level of regulation that might enhance gene expression in a heritable manner. Expand
Chromodomains are protein–RNA interaction modules
It is shown that association of MOF with the male X chromosome depends on its interaction with RNA, and MOF specifically binds through its chromodomain to roX2 RNA in vivo. Expand
DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome
It is proposed that DHX9 acts as a nuclear RNA resolvase that neutralizes the immediate threat posed by transposon insertions and allows these elements to evolve as tools for the post-transcriptional regulation of gene expression. Expand