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Tracking the ends: a dynamic protein network controls the fate of microtubule tips
Microtubule plus-end tracking proteins (+TIPs) are a diverse group of evolutionarily conserved cellular factors that accumulate at the ends of growing microtubules. They form dynamic networks throughExpand
Control of microtubule organization and dynamics: two ends in the limelight
The current knowledge of factors, including microtubule-targeting agents, that associate with micro Tubule ends to control the dynamics and function of microtubules during the cell cycle and development are reviewed. Expand
Mammalian Golgi‐associated Bicaudal‐D2 functions in the dynein–dynactin pathway by interacting with these complexes
It is shown here that a mammalian homologue of Bicaudal‐D, BICD2, binds to the dynamitin subunit of dynactin, and this interaction is confirmed by mass spectrometry, immunoprecipitation studies and in vitro binding assays. Expand
Structure-function relationship of CAP-Gly domains
The findings define the molecular basis of CAP-Gly domain function, including the tubulin detyrosination-tyrosination cycle, and establish fundamental roles for the interaction between CAP-gly proteins and C-terminal EEY/F sequence motifs in regulating complex and dynamic cellular processes. Expand
Microtubule minus-end stabilization by polymerization-driven CAMSAP deposition.
It is shown that CAMSAP2 is required for the proper organization and stabilization of interphase microtubules and directional cell migration and that katanin regulates this process. Expand
Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens
A conserved molecular ensemble that governs Rho activation during cytokinesis is used in interphase cells to control the Rho GTPase cycle at the zonula adherens. Expand
A Proteome-wide Screen for Mammalian SxIP Motif-Containing Microtubule Plus-End Tracking Proteins
A proteome-wide search for mammalian SxIP-containing +TIPs is performed by combining biochemical and bioinformatics approaches and identifies a set of previously uncharacterized EB partners that have the capacity to accumulate at the growing microtubule ends. Expand
Dynein Recruitment to Nuclear Pores Activates Apical Nuclear Migration and Mitotic Entry in Brain Progenitor Cells
By live imaging of in utero electroporated rat brain, it is found that two distinct G2-specific mechanisms for dynein nuclear pore recruitment are essential for apical nuclear migration. Expand
CFEOM1-associated kinesin KIF21A is a cortical microtubule growth inhibitor.
The identification of kinesin-4 KIF21A as an inhibitor of microtubule growth at the cell cortex provides mechanistic insight into cortical micro Tubule regulation and suggests that altered microtubules dynamics contribute to CFEOM1 pathogenesis. Expand
Dynamic microtubules regulate the local concentration of E-cadherin at cell-cell contacts
A pool of MTs that extend radially into cell-cell contacts and are inhibited by manoeuvres that block the dynamic activity of MT plus-ends is identified, indicating that dynamic MTs allow cells to concentrate E-cadherin at cell- cell contacts by regulating the regional distribution of E- cadher in once it reaches the cell surface. Expand