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Optimization of a Relative Telomere Length Assay by Monochromatic Multiplex Real-Time Quantitative PCR on the LightCycler 480: Sources of Variability and Quality Control Considerations.
Telomere length (TL) measurement is central to many biomedical research, population, and epidemiology studies, with promising potential as a clinical tool. Various assays are used to determine TL,Expand
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Rapid Decrease in Peripheral Blood Mononucleated Cell Telomere Length After HIV Seroconversion, but Not HCV Seroconversion
HIV-infected individuals show significantly shorter leukocyte telomere length compared with uninfected controls.1–4 This may translate to accelerated cellular aging and immunosenescence in the HIVExpand
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Leukocyte Telomere Length at Birth and During the Early Life of Children Exposed to but Uninfected With HIV After In Utero Exposure to Antiretrovirals
Background Maternal combination antiretroviral therapy (cART) during pregnancy could impact the health of human immunodeficiency virus (HIV)-exposed, HIV-uninfected (HEU) children, because someExpand
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Shorter granulocyte telomeres among children and adolescents with perinatally-acquired HIV infection and chronic lung disease in Zimbabwe.
BACKGROUND Chronic lung disease (CLD) has been reported among African children with perinatally-acquired HIV infection (C-PHIV), despite combination antiretroviral therapy (cART). In adults, shorterExpand
Robust Tobacco Smoking Self-Report in two Cohorts of Vulnerable Pregnant Women and Adults
Background Stigma associated with tobacco smoking, especially during pregnancy, may lead to underreporting and possible bias in studies relying on self-reported smoking data. Cotinine, a nicotineExpand
Blood mitochondrial DNA levels remain elevated from birth to early life in children HIV-exposed uninfected exposed to combination antiretroviral therapy in utero.
BACKGROUND Combination antiretroviral therapy (cART) during pregnancy prevents vertical transmission, but many antiretrovirals cross the placenta and several can affect mitochondria. Exposure toExpand
Chronic effect of carbaryl on the levels of total protein, total free amino acids and total glucose in the male reproductive system of Iphita limbata stål. (Heteroptera: Pyrrhocorridae)
the application of sub-lethal dose (0.6 μg/2 μl/insect) of carbaryl for a period of 60 days caused changes in the biochemical constituents in the male reproductive system of a heteropteran bug,Expand