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Gene-Specific Effects of Inflammatory Cytokines on Cytochrome P450 2C, 2B6 and 3A4 mRNA Levels in Human Hepatocytes
It is indicated that this fine control of P450 responses to inflammation are independently regulated and may have a critical effect on human drug responses in disease states. Expand
Regulation of drug-metabolizing enzymes and transporters in inflammation.
Regulation of hepatic flavin monooxygenases, UDP-glucuronosyltransferases, sulfotransferases, glutathione S-transferases and hepatic transporters during the inflammatory response, exhibits similarities and differences with regulation of CYPs. Expand
Roles of nitric oxide in inflammatory downregulation of human cytochromes P450.
It is demonstrated that the posttranscriptional NO-dependent downregulation of CYP2B enzymes, observed previously in rat hepatocytes, is conserved in human CYP1B6, and this mechanism is specific for CYP 2B6 among the enzymes tested. Expand
Expressed CYP4A4 metabolism of prostaglandin E(1) and arachidonic acid.
The enzyme was purified, and its activity with substrates prostaglandin E(1) (PGE(1)) and AA was examined, and a conformational change occurred in CYP4A4 protein upon binding of cyt b(5) or apo b( 5). Expand
■ Abstract CB1 and CB2 cannabinoid receptors are the primary targets of endogenous cannabinoids (endocannabinoids). These G protein–coupled receptors play an important role in many processes,Expand