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Mice devoid of PrP are resistant to scrapie
TLDR
These experiments show that PrPC, possibly at close to normal levels, is required for the usual susceptibility to scrapie and that lack of homology between incoming prions and the host's PrP genes retards disease. Expand
Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud
TLDR
It is reported that the c-met-encoded receptor tyrosine kinase is essential for migration of myogenic precursor cells into the limb anlage and for migration into diaphragm and tip of tongue. Expand
Prion protein (PrP) with amino‐proximal deletions restoring susceptibility of PrP knockout mice to scrapie.
TLDR
This work has introduced into PrP knockout mice transgenes encoding wild‐type PrP or PrP lacking 26 or 49 amino‐proximal amino acids which are protease susceptible in PrP(Sc), and found thatoculation with prions led to fatal disease, prion propagation and accumulation of PrP (Sc) in mice expressing both wild‐ type and truncated PrPs. Expand
Expression of Amino-Terminally Truncated PrP in the Mouse Leading to Ataxia and Specific Cerebellar Lesions
TLDR
PrP knockout mice expressing PrPs with amino-proximal deletions caused severe ataxia and neuronal death limited to the granular layer of the cerebellum as early as 1-3 months after birth, suggesting that these truncated PrPs may be nonfunctional and compete with some other molecule with a PrP-like function for a common ligand. Expand
Lines of Murine Oligodendroglial Precursor Cells Immortalized by an Activated neu Tyrosine Kinase Show Distinct Degrees of Interaction with Axons In Vitro and In Vivo
TLDR
These cell lines interact with neurons in vitro and in vivo and can be used as tools to define the molecules involved in different stages of neuron‐glia interaction. Expand
The AP-1 Transcription Factor c-Jun Is Required for Efficient Axonal Regeneration
TLDR
C-Jun is identified as an important regulator of axonal regeneration in the injured central nervous system and Expression of CD44, galanin, and alpha7beta1 integrin was greatly impaired, suggesting a mechanism for c-Jun-mediated axonal growth. Expand
Experimental autoimmune encephalomyelitis repressed by microglial paralysis
TLDR
The results validate CD11b-HSVTK mice as a tool to study the impact of microglial activation on CNS diseases in vivo and conclude that microglia paralysis inhibits the development and maintenance of inflammatory CNS lesions. Expand
An Analytical Solution to the Kinetics of Breakable Filament Assembly
TLDR
An analytical solution to the master equation shows that amyloid growth kinetics is often limited by the fragmentation rate rather than by the rate of primary nucleation, and reveals the existence of generic scaling laws that provide mechanistic information in contexts ranging from in vitro amyloids growth to the in vivo development of mammalian prion diseases. Expand
p62 Is a common component of cytoplasmic inclusions in protein aggregation diseases.
TLDR
The presence of p62 along with other stress proteins and ubiquitin in cytoplasmic inclusions indicates deposition as aggregates as a third line of defense against misfolded proteins in addition to refolding and degradation. Expand
Chronic wasting disease.
TLDR
Increased surveillance has unveiled several additional pockets of CWD-infected deer and elk in 12 additional states and 2 Canadian provinces, indicating that CWD infects free-ranging animals and is efficiently spread. Expand
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