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Axotomy results in delayed death and apoptosis of retinal ganglion cells in adult rats
Using quantitative anatomical techniques, we show that after intraorbital optic nerve transection in adult rats, virtually all retinal ganglion cells (RGCs) survive for 5 d and then die abruptly inExpand
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Effects of ocular injury and administration of brain-derived neurotrophic factor on survival and regrowth of axotomized retinal ganglion cells.
Optic nerve transection in adult rats results in the death of approximately 50% of the axotomized retinal ganglion cells (RGCs) by 1 week and nearly 90% by 2 weeks after injury. The capacity ofExpand
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Axonal elongation into peripheral nervous system "bridges" after central nervous system injury in adult rats.
The origin, termination, and length of axonal growth after focal central nervous system injury was examined in adult rats by means of a new experimental model. When peripheral nerve segments wereExpand
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Rapid and protracted phases of retinal ganglion cell loss follow axotomy in the optic nerve of adult rats.
To investigate the short- and long-term effects of axotomy on the survival of central nervous system (CNS) neurons in adult rats, retinal ganglion cells (RGCs) were labelled retrogradely with theExpand
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Expression of the growth-associated protein GAP-43 in adult rat retinal ganglion cells following axon injury
We have studied the expression of the growth-associated protein GAP-43 after injury to the axons of adult rat retinal ganglion cells (CNS neurons that do not normally regenerate injured axons). BothExpand
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Axons from CNS neurones regenerate into PNS grafts
Axons in the peripheral nervous system (PNS) and central nervous system (CNS) form sprouts after injury1–3. Elongation of regenerating axonal sprouts has been observed as the exception within theExpand
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Influences of peripheral nerve grafts on the survival and regrowth of axotomized retinal ganglion cells in adult rats
To investigate the role of extrinsic influences on the survival and growth of axotomized retinal ganglion cells (RGCs) in the mature mammalian CNS, both optic nerves (ONs) of adult rats wereExpand
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Axonal regeneration and synapse formation in the superior colliculus by retinal ganglion cells in the adult rat
In adult rats, one optic nerve was transected and replaced by a 4 cm segment of autologous peripheral nerve (PN) that linked one eye and the superior colliculus (SC) along a predominantlyExpand
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Prolonged delivery of brain-derived neurotrophic factor by adenovirus-infected Müller cells temporarily rescues injured retinal ganglion cells.
In this study, we demonstrate that: (i) injection of an adenovirus (Ad) vector containing the brain-derived neurotrophic factor (BDNF) gene (Ad.BDNF) into the vitreous chamber of adult rats resultsExpand
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Regeneration of long spinal axons in the rat
SummaryTo investigate regeneration of long spinal axons, the right lateral column of the rat spinal cord was cut at high cervical, low cervical, midthoracic or lumbar level, and one end of anExpand
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