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Risk of sudden death among young individuals with J waves and early repolarization: putting the evidence into perspective.
The presence of J waves and ST-segment elevation on the electrocardiogram (ECG), jointly termed "the early repolarization pattern," has traditionally been considered a marker of "good health."… Expand
Preventing sudden death of athletes with electrocardiographic screening: what is the absolute benefit and how much will it cost?
- A. Halkin, A. Steinvil, R. Rosso, A. Adler, U. Rozovski, S. Viskin
- Journal of the American College of Cardiology
- 4 December 2012
OBJECTIVES This study sought to estimate the costs of a national electrocardiographic (ECG) screening of athletes in the United States and the number of lives that would be saved by that program. … Expand
Risk stratification in Brugada syndrome: Clinical characteristics, electrocardiographic parameters, and auxiliary testing.
Risk stratification in Brugada syndrome remains a clinical challenge because the event rate is low but the presenting symptom is often cardiac arrest (CA). We review the data on risk stratification.… Expand
A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation
- N. Orr, R. Arnaout, +12 authors Michael H. Gollob
- Biology, Medicine
- Nature communications
- 12 April 2016
Atrial fibrillation (AF), the most common arrhythmia, is a growing epidemic with substantial morbidity and economic burden. Mechanisms underlying vulnerability to AF remain poorly understood, which… Expand
Brugada syndrome: diagnosis, risk stratification, and management
- A. Adler
- Current opinion in cardiology
- 1 January 2016
Purpose of review Asymptomatic patients with Brugada syndrome (BrS) have a small, but not trivial, risk of cardiac events. Their risk stratification and its impact on their management are… Expand
Prognostic significance of fever-induced Brugada syndrome.
BACKGROUND In Brugada syndrome (BrS), spontaneous type 1 electrocardiogram (ECG) is an established risk marker for fatal arrhythmias whereas drug-induced type 1 ECG shows a relatively benign… Expand
Diagnostic value of T-wave morphology changes during "QT stretching" in patients with long QT syndrome.
BACKGROUND Specific T-wave patterns on the resting electrocardiogram (ECG) aid in diagnosing long QT syndrome (LQTS) and identifying the specific genotype. However, provocation tests often are… Expand
An International, Multicentered, Evidence-Based Reappraisal of Genes Reported to Cause Congenital Long QT Syndrome
Supplemental Digital Content is available in the text. Background: Long QT syndrome (LQTS) is the first described and most common inherited arrhythmia. Over the last 25 years, multiple genes have… Expand
Derivation and Validation of a Simple Exercise-Based Algorithm for Prediction of Genetic Testing in Relatives of LQTS Probands
Background— Genetic testing can diagnose long-QT syndrome (LQTS) in asymptomatic relatives of patients with an identified mutation; however, it is costly and subject to availability. The accuracy of… Expand
Fever-induced Brugada pattern: how common is it and what does it mean?
BACKGROUND Fever is known to unmask the Brugada pattern on the electrocardiogram (ECG) and trigger ventricular arrhythmias in patients with Brugada syndrome. Genetic studies in selected cases with… Expand