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Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study
TLDR
In patients with type 2 diabetes the risk of diabetic complications was strongly associated with previous hyperglycaemia, with the lowest risk being in those with HbA1c values in the normal range (<6.0%). Expand
Association of systolic blood pressure with macrovascular and microvascular complications of type 2 diabetes (UKPDS 36): prospective observational study
TLDR
In patients with type 2 diabetes the risk of diabetic complications was strongly associated with raised blood pressure, with the lowest risk being in those with systolic blood pressure less than 120 mm Hg. Expand
Development and progression of nephropathy in type 2 diabetes: the United Kingdom Prospective Diabetes Study (UKPDS 64).
TLDR
Relatively fewer patients with type 2 diabetes develop macroalbuminuria, but in those who do, the death rate exceeds the rate of progression to worse nephropathy, and risk of death from all-causes or cardiovascular disease is high. Expand
The UKPDS risk engine: a model for the risk of coronary heart disease in Type II diabetes (UKPDS 56).
TLDR
The model is diabetes-specific and incorporates glycaemia, systolic blood pressure and lipid levels as risk factors, in addition to age, sex, ethnic group, smoking status and time since diagnosis of diabetes, which provides the estimates ofCHD risk required by current guidelines for the primary prevention of CHD in Type II diabetes. Expand
Unrelated Future Costs and Unrelated Future Benefits: Reflections on NICE Guide to the Methods of Technology Appraisal.
TLDR
It is argued that there is a sound principled reason for including both the costs and benefits of unrelated care in technology appraisals, and changed practice would have material consequences for decisions about reimbursing particular technologies. Expand
UKPDS 59: hyperglycemia and other potentially modifiable risk factors for peripheral vascular disease in type 2 diabetes.
TLDR
Hyperglycemia, as well as smoking, dyslipidemia, and blood pressure are potentially modifiable risk factors for the development of PVD. Expand
Prevalence and projections of diabetes and pre‐diabetes in adults in Sri Lanka—Sri Lanka Diabetes, Cardiovascular Study (SLDCS)
Aims  To determine the prevalence of diabetes mellitus and pre‐diabetes (impaired fasting glucose and impaired glucose tolerance) in adults in Sri Lanka. Projections for the year 2030 and factorsExpand
Lower-extremity amputation in diabetes. The independent effects of peripheral vascular disease, sensory neuropathy, and foot ulcers.
TLDR
This prospective study shows that peripheral sensory neuropathy, PVD, foot ulcers, former amputation, and treatment with insulin are independent risk factors for LEA in patients with diabetes. Expand
Effects of Aspirin for Primary Prevention in Persons with Diabetes Mellitus
TLDR
Aspirin use prevented serious vascular events in persons who had diabetes and no evident cardiovascular disease at trial entry, but it also caused major bleeding events. Expand
Risk Factors for Diabetic Peripheral Sensory Neuropathy: Results of the Seattle Prospective Diabetic Foot Study
TLDR
Poorer glycemic control increases the risk of neuropathy and is amenable to intervention, and height and age directly increase risk of Neuropathy and may help identify patients at risk. Expand
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