• Publications
  • Influence
The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors.
TLDR
The data suggest that TLRs sample the contents of the phagosome independent of the nature of the contents, and can establish a combinatorial repertoire to discriminate among the large number of pathogen-associated molecular patterns found in nature. Expand
Toll-like receptors in the induction of the innate immune response
TLDR
A group of proteins that comprise the Toll or Toll-like family of receptors perform this role in vertebrate and invertebrate organisms and it is therefore not surprising that studies of the mechanism by which they act has revealed new and important insights into host defence. Expand
Mechanisms of phagocytosis in macrophages.
TLDR
Macrophages also play an important role in the recognition and clearance of apoptotic cells; a notable feature of this process is the absence of an inflammatory response. Expand
The evolution of vertebrate Toll-like receptors.
TLDR
The complete sequences of Takifugu Toll-like receptor (TLR) loci and gene predictions from many draft genomes enable comprehensive molecular phylogenetic analysis and shows that coincidental evolution plays a minor role in TLR evolution. Expand
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
TLDR
It is reported that mammalian TLR5 recognizes bacterial flagellin from both Gram-positive and Gram-negative bacteria, and that activation of the receptor mobilizes the nuclear factor NF-κB and stimulates tumour necrosis factor-α production, and the data suggest thatTLR5, a member of the evolutionarily conserved Toll-like receptor family, has evolved to permit mammals specifically to detect flageLLated bacterial pathogens. Expand
Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via Ipaf
TLDR
It is shown here that cytosolic bacterial flagellin activated caspase-1 through Ipaf but was independent of Toll-like receptor 5, a known flageLLin sensor, which raises the possibility that the salmonella pathogenicity island 1 type III secretion system cannot completely exclude 'promiscuous' secretion of flagella. Expand
Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron
TLDR
This finding represents a new component of the innate immune system and the acute phase response to infection and limits bacterial growth by sequestrating the iron-laden siderophore. Expand
Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria
TLDR
It is demonstrated that activation of caspase-1 clears intracellular bacteria in vivo independently of IL-1β and IL-18 and establishes pyroptosis as an efficient mechanism of bacterial clearance by the innate immune system. Expand
Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome
TLDR
NLRC4/Ipaf detects the basal body rod component of the T3SS apparatus (rod protein) from S. typhimurium, which enables innate immune responses to virulent bacteria through a single pathway, a strategy that is divergent from that used by plants in which multiple NB-LRR proteins are used to detect T3 SS effectors or their effects on cells. Expand
Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility
TLDR
The exquisite ability of the innate immune system to precisely target a conserved site on flagellin that is essential for bacterial motility is demonstrated. Expand
...
1
2
3
4
5
...