• Publications
  • Influence
Arylamine N-acetyltransferases: from drug metabolism and pharmacogenetics to drug discovery
Arylamine N‐acetyltransferases (NATs) are polymorphic drug‐metabolizing enzymes, acetylating arylamine carcinogens and drugs including hydralazine and sulphonamides. The slow NAT phenotype increasesExpand
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Probing the architecture of the Mycobacterium marinum arylamine N-acetyltransferase active site
Treatment of latent tuberculosis infection remains an important goal of global TB eradication. To this end, targets that are essential for intracellular survival of Mycobacterium tuberculosis areExpand
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Piperidinols That Show Anti-Tubercular Activity as Inhibitors of Arylamine N-Acetyltransferase: An Essential Enzyme for Mycobacterial Survival Inside Macrophages
Latent M. tuberculosis infection presents one of the major obstacles in the global eradication of tuberculosis (TB). Cholesterol plays a critical role in the persistence of M. tuberculosis within theExpand
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Computational modeling of the bat HKU4 coronavirus 3CLpro inhibitors as a tool for the development of antivirals against the emerging Middle East respiratory syndrome (MERS) coronavirus
The Middle East respiratory syndrome coronavirus (MERS‐CoV) is an emerging virus that poses a major challenge to clinical management.
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Homology modeling of MCH1 receptor and validation by docking/scoring and protein-aligned CoMFA.
Homology modeling is becoming a valid method for obtaining three-dimensional coordinates for proteins. However, it is hard to judge the qualities of the resulting models warranting robust subsequentExpand
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Innovative computer-aided methods for the discovery of new kinase ligands.
Recent evidence points to significant roles played by protein kinases in cell signaling and cellular proliferation. Faulty protein kinases are involved in cancer, diabetes and chronic inflammation.Expand
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Analysis of β-amino alcohols as inhibitors of the potential anti-tubercular target N-acetyltransferase.
The synthesis and inhibitory potencies of a novel series of β-amino alcohols, based on the hit-compound 3-[3'-(4''-cyclopent-2'''-en-1'''-ylphenoxy)-2'-hydroxypropyl]-5,5Expand
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QSAR studies in the discovery of novel type-II diabetic therapies
Introduction: Type-II diabetes mellitus (T2DM) is a complex chronic disease that represents a major therapeutic challenge. Despite extensive efforts in T2DM drug development, therapies remainExpand
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Cholesterol metabolism: a potential therapeutic target in Mycobacteria
  • A. Abuhammad
  • Biology, Medicine
  • British journal of pharmacology
  • 1 July 2017
Tuberculosis (TB), although a curable disease, is still one of the most difficult infections to treat. Mycobacterium tuberculosis infects 10 million people worldwide and kills 1.5 million people eachExpand
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Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti‐tubercular agents using a fragment‐based drug design approach
With the emergence of extensively drug‐resistant tuberculosis, there is a need for new anti‐tubercular drugs that work through novel mechanisms of action. The meta cleavage product hydrolase, HsaD,Expand
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