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Autocrine Fibronectin Inhibits Breast Cancer Metastasis
3D polymer scaffolding is used to produce a fibrillar fibronectin matrix that induces an EMT-like event that includes phosphorylation of STAT3 and requires expression of β1 integrin, and suggests that autocrine fibronECTin production inhibits the metastatic potential of mesenchymal tumor cells. Expand
The Dynamic Relationship of Breast Cancer Cells and Fibroblasts in Fibronectin Accumulation at Primary and Metastatic Tumor Sites
A dynamic relationship between tumor and stromal cells within the tumor microenvironment is demonstrated, in which the levels and fibrillarization of FN in the extracellular matrix are modulated during the particular stages of disease progression. Expand
Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells
UBXN2A is introduced as a home defense response protein, which can reconstitute inactive p53-dependent apoptotic pathways and inhibit the binding between mot-2 and p53, which is an attractive therapeutic strategy in mot- 2-elevated tumors. Expand
Ubiquitin C‐Terminal Hydrolase L1: Biochemical and Cellular Characterization of a Covalent Cyanopyrrolidine‐Based Inhibitor
The deubiquitinase (DUB) ubiquitin C‐terminal hydrolase L1 (UCHL1) is expressed primarily in the central nervous system under normal physiological conditions. However, UCHL1 is overexpressed inExpand
Hyaluronic acid, CD44 and RHAMM regulate myoblast behavior during embryogenesis.
The data indicate that HA, through interactions with CD44 and RHAMM, promotes myogenic progenitor migration and proliferation and will be useful for the design of regenerative therapies that aim to promote the restoration of damaged or diseased muscle. Expand
A plant alkaloid, veratridine, potentiates cancer chemosensitivity by UBXN2A-dependent inhibition of an oncoprotein, mortalin-2
The VTD-dependent expression of UBXN2A is a potential candidate for designing novel strategies for colon cancer treatment, and VTD or its modified analogs offer a valuable adjuvant chemotherapy strategy to improve the efficacy of 5-FU-based chemotherapy for Colon cancer patients harboring WT-p53. Expand
Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy
Details are provided into the mechanistic role of UBXN2A as a potent mortalin inhibitor and as a potential chemotherapy sensitizer for clinical application and how three amino acids within the substrate-binding domain of mortalin are crucial for UBxN 2A binding to mortalin. Expand
Nucleocytoplasmic Translocation of UBXN2A Is Required for Apoptosis during DNA Damage Stresses in Colon Cancer Cells
It is shown that nucleocytoplasmic translocation of UBXN2A in response to stresses is necessary for its anti-cancer function in the cy toplasm, as well as activation of other mot-2-dependent growth promoting pathways. Expand
Diacrylamides as selective G-quadruplex ligands in in vitro and in vivo assays
The synthesis of previously unreported anthracene-9-monoacrylamides and anthracen-9,10-bisacrylamides and their potential as G-quadruplex ligands, based on preliminary fluorometric and biologicalExpand
Murine Myocardial Transcriptome Analysis Reveals a Critical Role of COPS8 in the Gene Expression of Cullin-RING Ligase Substrate Receptors and Redox and Vesicle Trafficking Pathways
The data are consistent with the notion that Cops8/CSN plays a role in the transcriptional regulation of CRL SRs and in the redox and vesicle trafficking pathways. Expand