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Functional diversity of helper T lymphocytes
The existence of subsets of CD4+ helper T lymphocytes that differ in their cytokine secretion patterns and effector functions provides a framework for understanding the heterogeneity of normal and… Expand
Cellular and Molecular Immunology
Cellular and molecular immunology , Cellular and molecular immunology , کتابخانه الکترونیک و دیجیتال - آذرسا
Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis.
Activation-induced cell death (AICD) of lymphocytes is an important mechanism of self-tolerance. In CD4+ T cells, AICD is mediated by the Fas pathway and is enhanced by IL-2. To define the mechanisms… Expand
Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death.
- L. van Parijs, Y. Refaeli, J. Lord, B. Nelson, A. Abbas, D. Baltimore
- Medicine, Biology
- 1 September 1999
IL-2 is an important growth and survival factor for T lymphocytes but also sensitizes these cells to Fas-mediated activation-induced cell death (AICD). The molecular basis of these different effects… Expand
Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-γ but not TH2 cytokines
A region of the interleukin-2 (IL-2) promoter known as the RE/AP element is activated in concert by signals that originate from the T cell antigen receptor and the CD28 coreceptor. We show here that… Expand
Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement.
- V. Perez, L. van Parijs, A. Biuckians, X. Zheng, T. Strom, A. Abbas
- Biology, Medicine
- 1 April 1997
Studies of T cell anergy in vitro have led to the widely accepted view that anergy is induced by T cell antigen recognition without costimulation. We show that the induction of T cell anergy in vivo… Expand
Basic Immunology : Functions and Disorders of the Immune System
Chapter 1: Introduction to the Immune System The Nomenclature, General Properties, and Components of the Immune System Chapter 2: Innate Immunity The Early Defense Against Infections Chapter 3:… Expand
Antigen-dependent Proliferation of CD4+ CD25+ Regulatory T Cells In Vivo
- L. Walker, A. Chodos, Mark P. Eggena, H. Dooms, A. Abbas
- Medicine, Biology
- The Journal of experimental medicine
- 21 July 2003
The failure of CD25+ regulatory T cells (Tregs) to proliferate after T cell receptor (TCR) stimulation in vitro has lead to their classification as naturally anergic. Here we use Tregs expressing a… Expand