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Functional diversity of helper T lymphocytes
The existence of subsets of CD4+ helper T lymphocytes that differ in their cytokine secretion patterns and effector functions provides a framework for understanding the heterogeneity of normal andExpand
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Cellular and Molecular Immunology
Cellular and molecular immunology , Cellular and molecular immunology , کتابخانه الکترونیک و دیجیتال - آذرسا
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Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis.
Activation-induced cell death (AICD) of lymphocytes is an important mechanism of self-tolerance. In CD4+ T cells, AICD is mediated by the Fas pathway and is enhanced by IL-2. To define the mechanismsExpand
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Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death.
IL-2 is an important growth and survival factor for T lymphocytes but also sensitizes these cells to Fas-mediated activation-induced cell death (AICD). The molecular basis of these different effectsExpand
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Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-γ but not TH2 cytokines
A region of the interleukin-2 (IL-2) promoter known as the RE/AP element is activated in concert by signals that originate from the T cell antigen receptor and the CD28 coreceptor. We show here thatExpand
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Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement.
Studies of T cell anergy in vitro have led to the widely accepted view that anergy is induced by T cell antigen recognition without costimulation. We show that the induction of T cell anergy in vivoExpand
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Basic Immunology : Functions and Disorders of the Immune System
Chapter 1: Introduction to the Immune System The Nomenclature, General Properties, and Components of the Immune System Chapter 2: Innate Immunity The Early Defense Against Infections Chapter 3:Expand
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Inmunología celular y molecular
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Antigen-dependent Proliferation of CD4+ CD25+ Regulatory T Cells In Vivo
The failure of CD25+ regulatory T cells (Tregs) to proliferate after T cell receptor (TCR) stimulation in vitro has lead to their classification as naturally anergic. Here we use Tregs expressing aExpand
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Imunologia celular e molecular
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