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NMR determination of Electrophorus electricus acetylcholinesterase inhibition and reactivation by neutral oximes.
Neurotoxic organophosphorus compounds (OPs), which are used as pesticides and chemical warfare agents lead to more than 700,000 intoxications worldwide every year. The main target of OPs is theExpand
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Nuclear magnetic resonance and molecular modeling study of exocyclic carbon–carbon double bond polarization in benzylidene barbiturates
Abstract Benzylidene barbiturates are important materials for the synthesis of heterocyclic compounds with potential for the development of new drugs. The reactivity of benzylidene barbiturates isExpand
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Quantitative nuclear magnetic resonance for purity assessment of polycyclic aromatic hydrocarbons
The application of 1H quantitative nuclear magnetic resonance (1H qNMR) for purity determination of organic compounds is well documented in the literature. The aim of this work is to determine if theExpand
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Synthesis and in vivo evaluation of 5-chloro-5-benzobarbiturates as new central nervous system depressants
A new family of barbiturates, 5-chloro-5-benzylbarbituric acids, was prepared using a simple efficient synthetic method from aromatic aldehydes and barbituric acid, followed by reduction andExpand
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Design, synthesis and in vivo evaluation of sodium 2-benzyl-chloromalonates as new central nervous system depressants
This work describes the design, synthesis and in vivo evaluation of new central nervous system depressing agents that show low levels of acute toxicity as well as high solubility in water and exhibitExpand