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A molecular basis for MHC class II--associated autoimmunity.
Class II major histocompatibility (MHC) molecules have an immunoregulatory role. These cell-surface glycoproteins present fragments of protein antigens (or peptides) to thymus-derived lymphocytes (T… Expand
Autoimmune diseases: the failure of self tolerance.
The ability to discriminate between self and nonself antigens is vital to the functioning of the immune system as a specific defense against invading microorganisms. Failure of the immune system to… Expand
A newly characterized HLA DQ beta allele associated with pemphigus vulgaris.
The inheritance of particular alleles of major histocompatibility complex class II genes increases the risk for various human autoimmune diseases; however, only a small percentage of individuals… Expand
Gene expression profile analysis by DNA microarrays: promise and pitfalls.
DNA microarrays represent a technological intersection between biology and computers that enables gene expression analysis in human tissues on a genome-wide scale. This application can be expected to… Expand
Prediction of desmoglein-3 peptides reveals multiple shared T-cell epitopes in HLA DR4- and DR6- associated Pemphigus vulgaris
- J. C. Tong, T. Tan, A. A. Sinha, S. Ranganathan
- Medicine, Computer Science
- BMC Bioinformatics
- 18 December 2006
Pemphigus vulgaris is a severe autoimmune blistering skin disorder that is strongly associated with major histocompatibility complex class II alleles DRB1*0402 and DQB1*0503. Expand
Oligonucleotide dot-blot analysis of HLA-DQβ alleles associated with multiple sclerosis
- A. A. Sinha, R. Bell, L. Steinman, H. Mcdevitt
- Biology, Medicine
- Journal of Neuroimmunology
- 1 April 1991
Oligonucleotide probes were used to investigate the role of DQ beta molecules in susceptibility to multiple sclerosis. Although shared amino acid and nucleotide sequences in DQ beta 1 have been… Expand
How a single amino acid change may alter the immunological information of a peptide.
What types of amino acid substitutions are functionally tolerated in an epitope? This question is of importance because the immunogenicity, pathogenicity, and therapeutic potential of a peptide can… Expand
NO LINKAGE OR ASSOCIATION OF TELOMERIC AND CENTROMERIC T‐CELL RECEPTOR β‐CHAIN MARKERS WITH SUSCEPTIBILITY TO TYPE 1 INSULIN‐DEPENDENT DIABETES IN HLA‐DR4 MULTIPLEX FAMILIES
- M. McDermott, G. Schmidt-Wolf, +11 authors D. Kastner
- Biology, Medicine
- European journal of immunogenetics : official…
- 1 October 1996
The T‐cell receptor β locus (TCRB) on chromosome 7q35 was studied as a candidate region for genetic susceptibility to type 1 insulin‐dependent diabetes (IDDM). A highly polymorphic microsatellite… Expand