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A molecular basis for MHC class II--associated autoimmunity.
Class II major histocompatibility (MHC) molecules have an immunoregulatory role. These cell-surface glycoproteins present fragments of protein antigens (or peptides) to thymus-derived lymphocytes (TExpand
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Autoimmune diseases: the failure of self tolerance.
The ability to discriminate between self and nonself antigens is vital to the functioning of the immune system as a specific defense against invading microorganisms. Failure of the immune system toExpand
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A newly characterized HLA DQ beta allele associated with pemphigus vulgaris.
The inheritance of particular alleles of major histocompatibility complex class II genes increases the risk for various human autoimmune diseases; however, only a small percentage of individualsExpand
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Gene expression profile analysis by DNA microarrays: promise and pitfalls.
DNA microarrays represent a technological intersection between biology and computers that enables gene expression analysis in human tissues on a genome-wide scale. This application can be expected toExpand
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Prediction of desmoglein-3 peptides reveals multiple shared T-cell epitopes in HLA DR4- and DR6- associated Pemphigus vulgaris
TLDR
Pemphigus vulgaris is a severe autoimmune blistering skin disorder that is strongly associated with major histocompatibility complex class II alleles DRB1*0402 and DQB1*0503. Expand
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Oligonucleotide dot-blot analysis of HLA-DQβ alleles associated with multiple sclerosis
Oligonucleotide probes were used to investigate the role of DQ beta molecules in susceptibility to multiple sclerosis. Although shared amino acid and nucleotide sequences in DQ beta 1 have beenExpand
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How a single amino acid change may alter the immunological information of a peptide.
What types of amino acid substitutions are functionally tolerated in an epitope? This question is of importance because the immunogenicity, pathogenicity, and therapeutic potential of a peptide canExpand
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NO LINKAGE OR ASSOCIATION OF TELOMERIC AND CENTROMERIC T‐CELL RECEPTOR β‐CHAIN MARKERS WITH SUSCEPTIBILITY TO TYPE 1 INSULIN‐DEPENDENT DIABETES IN HLA‐DR4 MULTIPLEX FAMILIES
The T‐cell receptor β locus (TCRB) on chromosome 7q35 was studied as a candidate region for genetic susceptibility to type 1 insulin‐dependent diabetes (IDDM). A highly polymorphic microsatelliteExpand
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