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Assessment of Interleukin‐1 Gene Cluster Polymorphisms in Lone Atrial Fibrillation: New Insight into the Role of Inflammation in Atrial Fibrillation
Systemic inflammation is accepted as one of the pathophysiological mechanisms of atrial fibrillation (AF). The role of inflammation has been shown previously. Interleukin (IL) system is the mainExpand
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Molecular chaperone properties of serum amyloid P component
The selective binding of serum amyloid P component (SAP) to proteins in the pathological amyloid cross‐β fold suggests a possible chaperone role. Here we show that human SAP enhances the refoldingExpand
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Lack of association between IL‐1 and IL‐6 gene polymorphisms and myocardial infarction in Turkish population
Inflammation and genetics play a key role in the pathogenesis of atherosclerosis and its clinical result myocardial infarction (MI). Proinflammatory cytokines, IL‐1 and IL‐6, have been shown to playExpand
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Association between sporadic Parkinson disease and interleukin-1 beta -511 gene polymorphisms in the Turkish population.
The pathogenesis of Parkinson Disease (PD) remains poorly understood; however, inflammation is thought to play an important role in disease progression. Recent reports suggest that IL-1, a majorExpand
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Inhibition of ornithine decarboxylase alters the roscovitine-induced mitochondrial-mediated apoptosis in MCF-7 breast cancer cells.
Polyamines (PAs) are small aliphatic amines that play a major role in multicellular functions. The PA levels are controlled by ornithine decarboxylase (ODC), the rate limiting enzyme of PAExpand
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Cathepsin K analysis in a pycnodysostosis cohort: demographic, genotypic and phenotypic features
BackgroundTo characterize cathepsin K (CTSK) mutations in a group of patients with pycnodysostosis, who presented with either short stature or atypical fractures to pediatric endocrinology orExpand
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Interleukin-1 receptor antagonist gene VNTR polymorphism is associated with coronary artery disease.
BACKGROUND Coronary Artery Disease (CAD) is the atherosclerosis of coronary arteries that carry blood to the heart muscle. Atherosclerosis is an inflammatory disease. Cytokine gene variations such asExpand
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Polyamine depletion enhances the roscovitine-induced apoptosis through the activation of mitochondria in HCT116 colon carcinoma cells
Small molecule inhibitors of cyclin-dependent kinases (CDKs) show high therapeutic potential in various cancer types which are characterized by the accumulation of transformed cells due to impairedExpand
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Silencing of the polyamine catabolic key enzyme SSAT prevents CDK inhibitor-induced apoptosis in Caco-2 colon cancer cells
Roscovitine and purvalanol are purine derivative cyclin-dependent kinase (CDK) inhibitors that induce apoptosis in various types of cancer cells. However, their impact on the apoptotic cell deathExpand
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Interleukin-1B (-511) gene polymorphism is associated with acute coronary syndrome in the Turkish population.
OBJECTIVES acute coronary syndrome (ACS) is defined as an inflammatory disease associated with development of atherosclerosis and instability. IL-1 is a candidate inflammatory cytokine that isExpand
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