A Z Ocaktan

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In order to identify and characterize the receptors involved in pyoverdin-mediated iron transport in Pseudomonas aeruginosa ATCC 15692, a photoactivatable siderophore has been synthesized. In the dark, this probe is stable and is able to promote iron transport at the same rate as the native pyoverdin. Under irradiation at 312 nm, the molecule is(More)
cin A (1) with a salt of streptolydigin. In our search for antibiotic substances from microorganisms, we isolated afragilimycin A from a Streptomyces sp. Afragilimycin A, described by Arai1}, does inhibit the growth of both Grampositive and Gram-negative bacteria, and has intermediate toxicity. Though several physical characteristics of the compoundsuch as(More)
Pseudomonas aeruginosa produces the siderophores pyoverdin and pyochelin as well as receptors for siderophores in response to iron deprivation. Previously, it has been shown in vitro that at neutral pH purified pyoverdin acquires iron from transferrin only in the presence of P. aeruginosa elastase (LasB), which proteolytically degrades transferrin. We(More)
The protective effect on iron-supplemented hepatocyte cultures of three iron chelators, pyoverdin Pa and hydroxypyrid-4-one derivatives CP20 and CP22, was compared to that of the widely known desferrioxamine B (Desferal:DFO), on the basis of two criteria: (a) their effectiveness in inhibiting free malondialdehyde (MDA) production as an index of iron-induced(More)
The effect of pyoverdin Pa A (an iron chelator isolated and purified from Pseudomonas aeruginosa ATCC 15692) was studied in rat hepatocyte cultures overloaded with iron. Iron overload was achieved by adding 80 mum-ferric nitrilotriacetate to the culture medium. One day after iron treatment, significant increases in aspartate aminotransferase and lactate(More)
The effect of the pyoverdin Pf (an iron chelating agent isolated and purified from Pseudomonas fluorescens CCM 2798) was studied on iron overloaded rat hepatocyte cultures. Iron overload was obtained by addition of 5-80 microM ferric nitrilotriacetate to the culture medium. Twenty-four hours after iron treatment, a significant increase in aspartate(More)
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