A. Yu. Tsibulevskii

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Seven days after bilateral subdiaphragmatic vagotomy in rats the mean diurnal number of mitoses in the jejunal epithelium is increased by 1.5 times. The character of the diurnal rhythm of mitosis is unchanged but fluctuations in the curve of mitotic activity are reduced. Vagotomy does not disturb the ratio between the volumes of cell populations of the(More)
Vagotomy is shown to result in disturbances of the microcirculation (a reduced rate of blood flow and distortion of its kinetics), the morphological basis of which consists of certain transformations of the microvascular network organization and ultrastructural changes in the cells lining the sinusoidal capillaries. The most pronounced disorders in(More)
Acute massive hemorrhage in rats is accompanied by consistent changes in the morphofunctional characteristics of erythrocytes: diameter, area, polarization, form factor, and integral and specific optical density. Thus, young initially intact rats showed significant increases in the mean diameter, area, and integral optical density at particular time points(More)
presence of many plasma cells in their tissues. Their large number in granulation tissue formed under dressings is undoubtedly attributed to the considerable microbial contamination of these wounds. Plasma cells are carriers of local immunity, and their presence in large numbers in granulations of wounds treated under dressings often leads ultimately to the(More)
Huch experimental evidence has been obtained to show that subdiaphragmatic vagotomy leads to the development of neurodystrophic changes in the digestive organs [3]. At the same time, a similar operation (truncal or selective vagotomy) is widely used in surgical practice for the treatment of duodenal ulcer. Consequently, the search for pathogenetic(More)
Evidence has been obtained in recent years to show that a definite role in the pathogenesis of the neurodystrophic changes developing in the digestive organs after division of the vagus nerves is played by hypoxia. For instance, vagotomy has been shown to lower the partial pressure of oxygen (pO2) in the liver, stomach, and small intestine [13]. A(More)
5. R. D. Seifulla, N. A. Onishchenko, S. D. Artamonov, et al., Farmakol. Toksikol., 42, No. 2, 157 (1979). 6. E. G. Bligh and W. J. Dyer, Can. J. Biochem. Physiol.,.37, 911 (1959). 7. H. van den Bosch, Biochim. Biophys. Acta, 604, 191 (1980). 8. C. De Duve, B. G. Pressman, R. Gianetto, et al., Biochem. J., 60, 604 (1955). 9. R. C. McKnight and F. E. Hunter,(More)
Bilateral subdiaphragmatic vagotomy in rats led to an increase in proliferative activity of the jejunal epithelium 7 days after the operation without any accompanying change in the diurnal rhythm of cell division. Meanwhile, after vagotomy the phase structure of the rhythm of DNA synthesis was modified in the intestinal epithelial cells: from the normal(More)
Hypoxia and activation of lipid peroxidation (LPO) are well known as pathogenic factors in the development of neurodystrophy of the digestive system as a result of damage to the parasympathetic innervation. It has been shown that vagotomy results in a decrease of the oxygen tension in the liver, stomach, and small intestine [7] and causes b iochemica l(More)
Vagal denervat ion of the s tomach is nowadays widely used ( separa te ly and in conjunction with other p ro cedures ) in the su rg ica l t r e a t m e n t of duodenal u l ce r s . Th is opera t ion can produce a las t ing d e c r e a s e in acid s ec re t i on in the s tomach and it thus provides a method of act ing on the m o s t impor tan t s tage in the(More)