A. Yu. Doroshevskaya

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Apoptosis markers (p53, PUMA, p21, and Mdm2) were studied in patients with rheumatoid arthritis at the early and late stages of disease on bone marrow smears and frozen sections of the articular synovial membrane. The target molecules were found in all patients. The early stage was characterized by maximum expression of antiapoptotic (Mdm2) molecule and the(More)
The pool of apoptosis regulator proteins (p53, PUMA, p21, and MDM2) in the bone marrow, lymph node, and other tumor substrate cells were studied by immunocytochemical analysis in patients with chronic lymphoproliferative diseases. Two groups of patients were distinguished, with the disease course differing by activities of the studied molecules. Activity of(More)
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