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1. Total body areal bone mineral density was measured by dual-energy X-ray absorptiometry in eight women before and 10 weeks after a very-low-calorie diet [405 kcal (1701 kJ)/day]. 2. The mean weight loss of 15.6 kg was accompanied by a statistically significant reduction in total body bone mineral density from 1.205 +/- 0.056 to 1.175 +/- 0.058 g/cm2 (mean(More)
Glycogen is stored in the liver, muscles, and fat cells in hydrated form (three to four parts water) associated with potassium (0.45 mmol K/g glycogen). Total body potassium (TBK) changes early in very-low-calorie diets (VLCDs) primarily reflect glycogen storage. Potassium released from glycogen can distort estimates of body composition during dieting. TBK(More)
Fraser et all in their original description of legionnaires' disease referred to three patients out of 182 with a WCC less than 2.0 x 109/1, two of whom died. Two other patients had WCCs of less than 6 0 x 109/1. During his acute illness our patient had pancytopenia with bone marrow depression. We can only speculate on the part played by legionnaires'(More)
Fat-free mass was measured by hydrodensitometry, electrical impedance and total body potassium before and after water and electrolyte loss induced by (a) the administration of the diuretic frusemide, and (b) sweat loss. All methods of measuring fat-free mass were shown by pilot experiments to have procedural reliability. The diuretic caused a reduction in(More)
Body composition, resting metabolic rate (RMR) and physical work capacity (aerobic capacity) were measured in four groups of 10 overweight women during 8 weeks of VLCD (405 kcal/day (42 g protein] followed by 8 weeks of 1500 kcal/day maintenance with two additional non dieting groups as controls. Five groups, i.e. two control groups plus three dieting(More)
The assumption that total energy expended is related to resting metabolic rate (RMR) has not been validated. Intuitively, weight lost should be determined by the difference between the total energy consumed and the total energy expended. The ratio of actual daily energy usage to RMR by subjects dieting for 11 wk on a 1695-kJ (405-kcal) very-low-calorie diet(More)
This paper presents 90-wk data on five seriously overweight subjects originally brought together for 1-2 wk in simple residential accommodation to share the experience of beginning a program of very-low-calorie dieting. All subjects have remained well below their starting weight; four of the five subjects have continued to lose weight (weight losses(More)
In assessing the desirability of very low calorie diets (VLCD) it is important to assess whether the additional calorie deprivation associated with a VLCD is within the range of physiological adaptation of normal people: specifically that the overweight person will return to normality in terms of body composition and metabolic rate. Comparison of fat free(More)
Body composition was assessed in naturally lean female subjects who never had need to diet. At BMI 21-22 their body weight distribution of 75 per cent FFM and 25 per cent fat was compared with subjects who had dieted below BMI 25 by various conventional self-selected diets; subjects who had dieted to BMI 21-22 by VLCD and subjects who were dieting with VLCD(More)