A. Watson

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The effects of a calcium antagonist, nimodipine, were tested on the response of the cerebral circulation to arterial pCO2 and blood pressure changes. The effects of reduced blood flow upon oedema formation and extracellular ion homeostasis under nimodipine preloading were studied. Both open and closed skull primate models were used, with alpha-chloralose(More)
BACKGROUND Genetic and environmental factors, including dietary copper intake, contribute to the pathogenesis of copper-associated hepatitis in Labrador retrievers. Clinical disease is preceded by a subclinical phase in which copper accumulates in the liver. OBJECTIVE To investigate the effect of a low-copper, high-zinc diet on hepatic copper(More)
BACKGROUND Circadian variation in renal toxicity of aminoglycosides has been demonstrated in animal and human studies. People with CF are frequently prescribed aminoglycosides. Altered pharmacokinetics of aminoglycosides are predictive of toxicity. AIM To investigate whether the time of day of aminoglycoside administration modulates renal excretion of(More)
On the ground of experiments on 6 baboons the authors tried to determined changes in the amplitude of the N10 somatosensory potential and the time of central neural conduction in relation to changes of the cerebral blood flow in subarachnoid haemorrhage. The following conclusions have been reached: the time of central neural conduction as well as the(More)
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