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Following mutagenesis of the human colorectal tumor cell line HCT C with ethyl methanesulfonate, clonal sublines were isolated that survived on medium toxic to cells expressing thymidylate synthase… Continue Reading
Structural analyses of bacterial thymidylate synthases (TSs) implicate a serine residue corresponding to Ser216 in human TS in hydrogen bond networks that are involved in binding of the nucleotide… Continue Reading
A 13-day-old premature infant with hyaline membrane disease was found to have altered pneumocytes, suggesting viral infection. Pneumocytes had nuclear inclusions that were basophilic or eosinophilic… Continue Reading