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The use of high-frequency ultrasound transducers combined with manometry in the gastrointestinal (GI) tract has yielded important findings concerning the anatomy, physiology, and pathophysiology of the high-pressure zone of the gastroesophageal junction and the sphincteric muscles within. These transducers have made previously invisible portions of the GI(More)
BACKGROUND We sought to determine how the individual components of the distal esophagus and proximal stomach form the gastroesophageal junction high-pressure zone (GEJHPZ) antireflux barrier. METHODS An endoscopic ultrasound/manometry catheter was pulled through the proximal stomach and distal esophagus in 20 normal subjects. The axial length and width of(More)
Relaxation of gastric clasp and sling muscle fibers is involved the transient lower esophageal sphincter relaxations underlying the pathophysiology of gastroesophageal reflux disease (GERD). These fibers do not contribute tone to the high-pressure zone in GERD patients, indicating their role in pathophysiology. This study identifies some mediators of the(More)
It was recently shown that the tonic pressure contribution to the high-pressure zone of the oesophago-gastric segment (OGS) contains the contributions from three distinct components, two of which are smooth muscle intrinsic sphincter components, a proximal and a distal component [J Physiol 2007; 580.3: 961]. The aim of this study was to compare the pressure(More)
AIM To study the angle between the circular smooth muscle (CSM) and longitudinal smooth muscle (LSM) fibers in the distal esophagus. METHODS In order to identify possible mechanisms for greater shortening in the distal compared to proximal esophagus during peristalsis, the angles between the LSM and CSM layers were measured in 9 cadavers. The outer(More)
AIM To explore whether patients with a defective ileocecal valve (ICV)/cecal distension reflex have small intestinal bacterial overgrowth. METHODS Using a colonoscope, under conscious sedation, the ICV was intubated and the colonoscope was placed within the terminal ileum (TI). A manometry catheter with 4 pressure channels, spaced 1 cm apart, was passed(More)
BACKGROUND There is no simple method to measure intravariceal pressure in patients with esophageal varices. OBJECTIVE Our purpose was to develop a new noninvasive technique to measure resting intravariceal pressure and wall tension. DESIGN A model was developed. A long balloon (varix) was fitted inside an airtight cylinder (esophagus). Fluid ran through(More)
BACKGROUND Proper function of the gastro-esophageal high pressure zone is essential for the integrity of the antireflux barrier. Mechanisms include tonic contractions and the decreased tone during transient lower esophageal sphincter relaxations. METHODS We characterized the pharmacology of nicotinic receptors mediating relaxations of the human upper(More)
1 Contraction by M2 and M3 Muscarinic Receptors 2 Anil K. Vegesna, Alan S. Braverman, Larry S. Miller, Ronald J. Tallarida, Mansoor 3 I. Tiwana, Umar Khayyam and Michael R. Ruggieri, Sr. 4 5 Departments of Medicine, Urology, Pharmacology, and Center for Substance Abuse. 6 Temple University School of Medicine, Philadelphia, Pennsylvania. 7 8 Running head: M2(More)
BACKGROUND More than 66% of adults in United States are overweight or obese. OBJECTIVE To decrease gastric emptying and cause early and prolonged satiety by endoscopically narrowing the gastric pylorus. DESIGN Thirteen dogs were randomized into 3 groups (suture, sham, and control). SETTING Animal facility. INTERVENTIONS Sutures were placed across(More)