Learn More
Neurons seem to have at least two self-destruct programs. Like other cell types, they have an intracellular death program for undergoing apoptosis when they are injured, infected, or not needed. In addition, they apparently have a second, molecularly distinct self-destruct program in their axon. This program is activated when the axon is severed and leads(More)
Here, we use a mouse model (DBA/2J) to readdress the location of insult(s) to retinal ganglion cells (RGCs) in glaucoma. We localize an early sign of axon damage to an astrocyte-rich region of the optic nerve just posterior to the retina, analogous to the lamina cribrosa. In this region, a network of astrocytes associates intimately with RGC axons. Using(More)
Glaucoma is a common neurodegenerative disease that affects retinal ganglion cells (RGCs). Substantial effort is being expended to determine how RGCs die in glaucoma. As in other neurodegenerative diseases, the majority of effort focuses on characterising apoptotic self-destruct pathways. However, apoptosis is not the only self-destruct mechanism that may(More)
The spectral absorbances of visual pigments and retinal oil droplets were studied in three groups of Japanese quail (Coturnix coturnix japonica): an unselected control population and two artificially selected strains that exhibited different early approach preferences between blue and red stimuli. The oil droplets were examined with and without prior(More)
Asymmetric segregation of cell-fate determinants during cytokinesis plays an important part in controlling cell-fate choice in invertebrates. During Drosophila neurogenesis, for example, asymmetric segregation of the Numb protein, which inhibits Notch signaling, is necessary for the two daughter cells of a division to have different fates. In vertebrates,(More)
Melanin, or products directly associated with it, regulates the maturation of the neural retina because in hypopigmented mammals the central retina fails to develop fully. To determine whether this deficit is reflected in the distribution of photoreceptors, their topography has been studied in the retinae of normally reared pigmented and albino ferrets and(More)
In recent years a number of electrophysiological and psychophysical observations have suggested that the temporal properties of the human longwave- and middlewave-sensitive cones might be different. However, until now the issue has remained unresolved, despite its obvious importance. We have succeeded in probing, electrophysiologically, the temporal(More)
Recent studies have highlighted a potential link between the cleavage orientation of a dividing neuroblast and the regulation of daughter cell fate in the developing vertebrate retina. There is evidence to suggest that this process is at least partially regulated by the presence of the retinal pigment epithelium (RPE) and/or RPE-derived factors. In addition(More)
Neurodegenerative diseases are complex multifactorial disorders characterised by the interplay of many dysregulated physiological processes. As an exemplar, Parkinson's disease (PD) involves multiple perturbed cellular functions, including mitochondrial dysfunction and autophagic dysregulation in preferentially-sensitive dopamine neurons, a selective(More)
In this paper we provide a method to assess whether a subnetwork constructed from a seed list (a list of nodes known to be important in the area of interest) differs significantly from a randomly generated subnetwork. Our work is motivated by an interest in constructing a protein-protein interaction network that captures key features associated with(More)