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Kainate receptor agonists are powerful convulsants and excitotoxins. It has been a lot of controversy around functions of these receptors in the brain. It is shown in this article that kainate enhances evoked GABAergic IPSC (phasic currents) in CA1 interneurons in concentration-dependent manner. The phenomenon is likely to be due to kainate-mediated… (More)
Glutamate and GABA are major synaptic neurotransmitters in the hippocampus. However, their action is not confined to restricted postsynaptic area. A number of sources, such as reversed uptake, glial exocytosis, osmotically driven release, and neurotransmitter spillover can build up the extracellular concentration of these amino acids. GABA and glutamate… (More)