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Glutamate and GABA are major synaptic neurotransmitters in the hippocampus. However, their action is not confined to restricted postsynaptic area. A number of sources, such as reversed uptake, glial exocytosis, osmotically driven release, and neurotransmitter spillover can build up the extracellular concentration of these amino acids. GABA and glutamate… (More)
Kainate receptor agonists are powerful convulsants and excitotoxins. It has been a lot of controversy around functions of these receptors in the brain. It is shown in this article that kainate enhances evoked GABAergic IPSC (phasic currents) in CA1 interneurons in concentration-dependent manner. The phenomenon is likely to be due to kainate-mediated… (More)