Glutamate and GABA are major synaptic neurotransmitters in the hippocampus. However, their action is not confined to restricted postsynaptic area. A number of sources, such as reversed uptake, glial exocytosis, osmotically driven release, and neurotransmitter spillover can build up the extracellular concentration of these amino acids. GABA and glutamate… (More)
Kainate receptor agonists are powerful convulsants and excitotoxins. It has been a lot of controversy around functions of these receptors in the brain. It is shown in this article that kainate enhances evoked GABAergic IPSC (phasic currents) in CA1 interneurons in concentration-dependent manner. The phenomenon is likely to be due to kainate-mediated… (More)
In the review, it is presented an analysis of experimental data about cellular and molecular mechanisms of focal epileptogenesis. Basic principals of synchronized burst activity development in epileptogenic focus are considered. The roles of synaptic activities and extrasynaptic membrane excitability for epileptiform activity development are discussed. The… (More)
The Krushinsky-Molodkina rat CA1 hippocampal slices revealed an increased threshold of the epileptiform activity development, a depressed signal transmission in the presynaptic glutamatergic fibres, no long-term increase in excitability of the CA1 pyramidal neurons characteristic of Wistar rats following Mg2+ removal and K+ increase. These events suggest a… (More)
Short-term repeated increases of extracellular K+ resulted in occurrence of a kindling-like phenomenon in local neuronal network of the CA1 region in hippocampal slices. The phenomenon well correlated with the ES potentiation. The role of various Ca2+ channels in this phenomenon is discussed.