A. V. Khrabrova

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A relationship between the indices of efficacy of the muscarinic antagonists in preventing the haloperidol catalepsy and their activity in the tests characterizing the interaction of these ligands with various subtypes of m-cholinoreceptors was studied in rats. A mathematical model was formulated that confirmed the previous conclusion concerning the role of(More)
307 The involvement of disturbances in the functional state of dopaminergic neurotransmitter system in the pathogenesis of Parkinsonian like disorders, including Parkinson’s disease as a separate ilness, as well as sev eral other pathologies determined by the effects of xenobiotics and some drugs, is now generally accepted. The use of selective dopamine(More)
Experiments on rodents showed that pentifin, a muscarine antagonist belonging to the group of acetylene amines, possesses a pronounced antiparkinsonian activity. Pentifin is superior in the breadth of therapeutic action and tolerance characteristics to the conventional agents used for Parkinson's disease treatment.
The dependence between the activity parameters of muscarine antagonists in the prevention of haloperidol catalepsy in rats and those in tests characterizing the interaction of ligands and various subtypes of m-cholinoceptors was studied. It was established by constructing the mathematical dependence that blockade of m1-cholinoceptors increases, while that(More)
Quantitative assessment of selective blockade of M4-subtype muscarinic receptors was performed by the number of pilocarpine-induced movements of lower jaw in rats. Three antagonists (atropine, cyclodol, and glipin) were used in the experiments. Glipin produced the most potent blockade of M4 receptors in the whole organism compared to other test antagonist.
The effects of citalopram, olanzapine and their combinations were studied in tests on outbred SHR male mice. The locomotor activity was determined in the open field, the antidepressant effects - in the tail suspension test, the anxiety-like behavior- in the light-dark transition test; in addition, the antidopaminergic effects of drugs and their combination(More)
We studied the relationship between the efficiency of muscarinic receptor antagonists in preventing haloperidol-induced catatonia and their activity in tests for the interaction of ligands with various subtypes of muscarinic receptors (M1-M4) in rats. Mathematical modeling showed that affinity of the ligand for M4 receptors positively affects its ability to(More)
We studied the functional role of individual subtypes of muscarinic cholinoceptors in the pathogenesis of neuroleptic parkinsonism in rats. Blockade of M4 receptors prevented the development of extrapyramidal disorders, which was abolished by simultaneous blockade of M2 receptors. The data suggest that various subtypes of muscarinic receptors are involved(More)
The effect of the selectivity of cholinopositive compounds on atropin antiparkinsonian activity was compared in experiments on rats. The selectivity of the effect of two new synthesized cholinopositive compounds of the phenylcarbamate group was evaluated in preliminary experiments. It was determined by means of these compounds that stimulation of(More)
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