A. V. Gabrelian

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We studied the effect of somatostatin on presinaptic NMDA receptors and postsinaptic GABA, NMDA, and AMPA receptors in rat brain. It was shown that somatostatin inhibits NMDAinduced 45Ca2+ uptake into synaptosomes isolated from rat brain cortex (IC50=2.8×10–11 M). Somatostatin potentiates AMPA receptors and inhibits hippocampal NMDA receptors in the entire(More)
We studied the effect of prostaglandins on presynaptic NMDA receptors. Prostaglandin E2 inhibited NMDA-induced (45)Ca2+ uptake by synaptosomes in low concentrations (IC50 approximately 10 microM), but potentiated it in higher concentrations. Prostaglandin D2 increased (45)Ca2+ uptake by synaptosomes during stimulation of NMDA receptors. Our results indicate(More)
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