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Low-density lipoprotein (LDL) cholesterol lowering is a primary goal in clinical management of patients with cardiovascular disease, but traditional cholesterol levels may not accurately reflect the true atherogenicity of plasma lipid profiles. The size and concentration of lipoprotein particles, which transport cholesterol and triglycerides, may provide(More)
This paper examines an attempt made in a series of articles (Stanley, 2002, et al. ) to create a syntactic placeholder for contextual information. The initial shortcoming of Stanley ’ s proposal is that it does not easily integrate these placeholders with domain-restricting information syntactically encoded elsewhere in the utterance. Thus, Stanley makes(More)
BACKGROUND Healthy lifestyle changes are thought to mediate cardiovascular disease risk through pathways affecting endothelial function and progression of atherosclerosis; however, the extent, persistence, and clinical significance of molecular change during lifestyle modification are not well known. We examined the effect of a rigorous cardiovascular(More)
A case of infectious mononucleosis complicated by hepatic involvement is reported. Serial liver biopsy studies revealed a lesion indistinguishable from viral hepatitis. The suggestion is made that though mononucleosis hepatitis is milder than infectious hepatitis, the pathologic changes occurring in the liver in these diseases may be the same and differ(More)
BACKGROUND Under combat conditions infectious disease can become a major threat to military forces. During Operation Desert Shield, there were numerous outbreaks of diarrhea among the U.S. forces. To evaluate the causes of and risk factors for diarrheal disease, we collected clinical and epidemiologic data from U.S. troops stationed in northeastern Saudi(More)
Three phase 1 studies of eliglustat tartrate (Genz-112638), an oral inhibitor of glucosylceramide synthase under development for treating Gaucher disease type 1 (GD1), evaluated the safety, tolerability, and pharmacokinetics in healthy volunteers after escalating single doses (n = 99), escalating multiple doses (n = 36), and food (n = 24). Eliglustat(More)
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