A. V. Belyavskii

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We studied umbilical cord blood mesenchymal stem cells and compared mesenchymal stem cells derived from umbilical cord blood, adipose tissue, and skin. Umbilical cord blood mesenchymal stem cells were characterized morphologically, cytofluorometrically, and by their differentiation potential. Umbilical cord blood mesenchymal stem cells did not differ from(More)
We compared differentiation potential of mesenchymal stem cells originating from human bone marrow, fatty tissue, thymus, placenta, and skin. The cells were characterized by differentiation into adipocytes and osteoblasts. Mesenchymal stem cells from different sources exhibited different differentiation potential, manifesting by the rate of differentiation(More)
In order to verify the relationship between the expression of Notch ligand in NIH 3T3 fibroblast clones and maintenance of hemopoietic activity in vitro, monolayers from three clones were co-cultured with mouse bone marrow mononuclears for 1–4 weeks and the total production of hemopoietic cells and myeloid colony-forming activity in methylcellulose were(More)
The development of antitumor preparations with low toxicity and high selectivity of action is one of the top priorities of cancer gene therapy. Mesenchymal stem cells possess natural tropism towards tumors, a property that makes it possible to use them as vehicles for the targeted delivery of therapeutic genes to tumors of various etiologies. At present,(More)
We studied the possibility of long-term culturing of mouse mesenchymal stem cells on a porous scaffold made of biocompatible polymer poly-3-hydroxybutyrate. The cells remained viable for at least 2 months and passed more than 65 population doublings in culture. Culturing on the scaffold did not change surface phenotype of cells. 3D poly-3-hydroxybutyrate(More)
32 Therapeutic neovascularization of ischemic organs is one of the most prospective directions of application of gene therapy. The main strategy for neovascularization with the use of gene therapy is the expression of angioand arteriogenic factors, such as VEGF, FGF-1, HGF, etc. [1–3] and, currently, some protective factors (e.g., hemoxygenase 1) [4].(More)
138 Expression of genes that control hematopoiesis was studied in the stroma-derived cell lines obtained from the long-term cultures of bone marrow from TNF-deficient mice. The level of N-cadherin gene expression in hematopoiesis-maintaining cells lines was 15 times higher than in the stromal cell sublayer of long-term cultures of the wild-type bone marrow.(More)
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