A. Tairi

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Fluorescent 2'-deoxynucleotides containing a protecting group at the 3'-O-position are reversible terminators enabling array-based DNA sequencing by synthesis (SBS) approaches. Herein, we describe the synthesis of a new family of 3'-OH unprotected cleavable fluorescent 2'-deoxynucleotides and their evaluation as reversible terminators for high-throughput(More)
A serotonin 5-HT3 receptor was functionally expressed to high levels and on a large scale in mammalian cells with the Semliki Forest virus system. Conditions were optimized to maximize detergent solubilization of the receptor, while preserving ligand binding activity. An efficient one-step purification yielding approximately 50% of the histidine-tagged(More)
In this paper, an Ant Colony Optimization Algorithm (ACO) is proposed for operations of steady flow gas pipeline. The system is composed of compressing stations linked by pipe legs. The decisions variables are chosen to be the operating turbo compressor number and the discharge pressure for each compressing station. The objective function is the power(More)
Optimization of large gas trunk-lines known as IGAT results in reduced fuel consumption or higher capability and improves pipeline operation. In the current study, Single and Multi-objective optimizations were conducted for a compressor station comprising four similar compressor units driven by four similar gas turbines, four coolers of the same size and a(More)
A new class of cleavable fluorescent nucleotides: synthesis and optimization as reversible terminators for DNA sequencing by synthesis ABSTRACT Fluorescent 2'-deoxynucleotides containing a protecting group at the 3'-O-position are reversible terminators enabling array-based DNA sequencing by synthesis (SBS) approaches. Herein, we describe the synthesis of a(More)
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