A. Srinivas Reddy

Learn More
The present study of genetic analysis is an attempt to precisely characterize diverse temperature-sensitive genic male-sterile (TGMS) lines so as to explore the possibilities of utilizing the most promising in large-scale hybrid seed production. Genetical studies revealed that the TGMS segregants derived from crosses involving TGMS lines ID24 and SA2(More)
An understanding of the molecular mechanisms that are responsible for increased oleic acid accumulation would open avenues to alter peanut fatty acid composition and allow detection of polymorphic regions which can be used for marker assisted selection (MAS). Δ12-Fatty acid desaturase (FAD) was isolated and characterized from genotypes having a low or high(More)
Virtual screening emerged as an important tool in our quest to access novel drug like compounds. There are a wide range of comparable and contrasting methodological protocols available in screening databases for the lead compounds. The number of methods and software packages which employ the target and ligand based virtual screening are increasing at a(More)
The intergenic spacer derived from a cloned rDNA unit from a cultivated rice was dissected into several subclones, which were used as probes to analyze sequence homologies between rDNA spacers from wild rice belonging to genome types AA, BB, CC, EE, FF, BBCC, and CCDD. This analysis allowed us to detect several regions with different degrees of homology. A(More)
The prediction of biological activity of a chemical compound from its structural features plays an important role in drug design. In this paper, we discuss the quantitative structure activity relationship (QSAR) prediction models developed on a dataset of 170 HIV protease enzyme inhibitors. Various chemical descriptors that encode hydrophobic, topological,(More)
In the present work, we address an apparent disparity in the structural parameters of the X-ray structures and theoretical models of cation-pi complexes in biological and chemical recognition. Hydrated metal ion (Li+, Na+, K+, Mg2+, Ca2+) complexes with benzene (cation-pi) are considered as model systems to perform quantum mechanical calculations in(More)
A 352-bp EcoRI fragment from rice DNA was cloned and shown to be a member of a tandem repeat. Sequence determination revealed homologies with human alpha satellite DNA and maize knob heterochromatin specific repeat. This 352-bp sequence is highly specific for the AA genome of rice. However, copy number and sequence organization are variable, depending on(More)
A comprehensive database named, protein ligand interaction database (PLID), is created with 6295 ligands bound to proteins extracted from the protein data bank (PDB). This is by far the most comprehensive database of physico-chemical properties, quantum mechanical descriptors and the residues present in the active site of proteins. It is a publicly(More)
In recent years, even with remarkable scientific advancements and a significant increase of global research and development spending, drugs are frequently withdrawn from markets. This is primarily due to their side effects or toxicities. Drug molecules often interact with multiple targets, coined as polypharmacology, and the unintended drug-target(More)