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By binding growth factors (GFs), the ECM tightly regulates their activity. We recently reported that the heparin-binding domain II of fibronectin acts as a promiscuous high-affinity GF-binding domain. Here we hypothesized that fibrin, the provisional ECM during tissue repair, also could be highly promiscuous in its GF-binding capacity. Using multiple(More)
We consider certain quadrature rules of highest algebraic degree of precision that involve strong Stieltjes distributions (i.e., strong distributions on the positive real axis). The behavior of the parameters of these quadrature rules, when the distributions are strong c-inversive Stieltjes distributions, is given. A quadrature rule whose parameters have(More)
Inducing organogenesis in 3D culture is an important aspect of stem cell research. Anterior neural structures have been produced from large embryonic stem cell (ESC) aggregates, but the steps involved in patterning such complex structures have been ill defined, as embryoid bodies typically contained many cell types. Here we show that single mouse ESCs(More)
The development of new drugs is currently a long and costly process in large part due to the failure of promising drug candidates identified in initial in vitro screens to perform as intended in vivo. New approaches to drug screening are being developed which focus on providing more biomimetic platforms. This review surveys this new generation of drug(More)
We investigate polynomials satisfying a three-term recurrence relation of the form B n (x) = (x − β n)B n−1 (x) − α n xB n−2 (x), with positive recurrence coefficients α n+1 , β n (n = 1, 2,. . .). We show that the zeros are eigenvalues of a structured Hessenberg matrix and give the left and right eigenvectors of this matrix, from which we deduce Laurent(More)
We study polynomials which satisfy the same recurrence relation as the Szeg˝ o polynomials, however, with the restriction that the (reflection) coefficients in the recurrence are larger than one in modulus. Para-orthogonal polynomials that follow from these Szeg˝ o polynomials are also considered. With positive values for the reflection coefficients, zeros(More)