A Shlyakhter

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In this paper we describe a simulation, by Monte Carlo methods, of the results of rodent carcinogenicity bioassays. Our aim is to study how the observed correlation between carcinogenic potency (beta or 1n2/TD50) and maximum tolerated dose (MTD) arises, and whether the existence of this correlation leads to an artificial correlation between carcinogenic(More)
Correlations between carcinogenic potency (p or I,/TDsa) and acute toxicity (I-D& and between carcinogenic potency and maximum tolerated dose (MTD) have been described by several authors (l-5). The correlations have been attributed in part to a bias inherent in the carcinogenicity bioassay, namely, that the carcinogenic potencies of chemicals that are(More)
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