A. S. Tiganov

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Analysis of EEG spectral power values and quantitative clinical scores of depressive conditions has been carried out in the dynamics of the treatment of 40 patients with endogenous depression, with the main goal to study the neurophysiological correlates and to search for possible predictors of therapeutic outcome. The reduction of depressive symptoms by(More)
A classification of endogenous affective disorders based on clinical manifestations of a concrete disease is proposed. It reflects one of the stages of investigations into the structure of psychopathological manifestations of depressive and maniacal disorders. Further studies may provide data for the adjustment of the classification to the current(More)
The authors analyse the trends in the study of childhood autism in the XX century and state of the art in view of nosology, systematics, clinical phenomenology, etiology and pathogenesis of autistic disorders. Mental Health Research Center of Russian Academy of Medical Sciences proposes a new classification of autism in children basing on the study of 500(More)
Bipolar disorder (BD) is a severe and highly heritable neuropsychiatric disorder with a lifetime prevalence of 1%. Molecular genetic studies have identified the first BD susceptibility genes. However, the disease pathways remain largely unknown. Accumulating evidence suggests that microRNAs, a class of small noncoding RNAs, contribute to basic mechanisms(More)
The author considers the problem of pathomorphosis, i.e. the changes in clinical presentation of endogenous mental diseases (schizophrenia, depression), since the time of its classical description. There is a general trend towards the development of forms with more favorable course in schizophrenia and the domination of prolonged and masked variants in(More)
The significant variety of psychopathological presentations of depression causes difficulties in its diagnosis. Depression of middle age is subdivided depending on the predomination of one or another disorder in the clinical picture. There are simple depression and complicated depression with additional psychopathological symptoms. The most difficult is to(More)
An analysis of EEG spectral power values and of quantitative clinical scores of depressive conditions has been carried out in dynamics of treatment in 40 patients with endogenous depression with the main goal to study neurophysiologic correlates and to search possible predictors of therapeutic outcome. The reduction of depressive symptoms by the end of the(More)
The latest advances in molecular medicine, medical genetics and neurobiology have provided for a new look at processes occurring in cells of the brain and have allowed to discover previously unknown phenomena associated with mental traits and to propose new biomedical direction which include genomics, psychiatry and neurobiology - brain genomics. The(More)
The clinical picture of paroxysm-like progredient schizophrenia in 104 patients was characterized by a combination of schizophrenic symptomatology, paroxismal and paroxysm-like disorders. Investigation of their psychopathological structure showed that they differ from that of epileptic paroxysms. The data obtained provide a basis for distinguishing a(More)
Approaches to diagnosing schizophrenia are different. There is a distinct tendency either to narrow the limits of the disease or to expand it, which in some cases leads to a disagreement and even a tendency to disputes. The comprehensive studies conducted in the Mental Health Research Center, Russian Academy of Medical Sciences, have provided an overall(More)