A. S. Ol'shanskii

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After a lesion of serotoninergic neurons performed by administration of 5.7-dihydroxytriptamine into the dorsal raphe nucleus, effects of neurotensin microinjections into the substantia nigra on rat behavior were investigated. Serotoninergic lesions resulted in enhanced fear of rats manifested as an increase in the number of intersignal avoidance reactions(More)
The studies reported here demonstrate that microinjection of neurotensin into the caudate nucleus of the rat brain facilitated extinction of a conditioned motor reflex with reinforcement provided by drinking. Neurotensin had positive effects on the process of post-extinction inhibition in subsequent experiments. Neurotensin microinjections had no marked(More)
After serotonergic lesion by administration of 5,7-dihydroxytryptamine into the dorsalis raphe nucleus, effects of neurotensin microinjections into the caudate nucleus and substantia nigra on rat behavior were compared. Serotonergic lesions resulted in motivated excitement of rats manifested as an increase in the number of intersignal motor reactions during(More)
The purpose of the study was to reveal the features of the influence of neurotensin injected into the nucleus accumbens on behaviour of rats after systemic administration of reserpine in the dose of 2 mg/kg. Reprodution of passive avoidance conditioned reactions, painful stimulation aftereffects on locomotor activity in the "open field", and behavior in the(More)
The purpose of the research was to reveal the features of neurotensin influence on behavior of rats with damages of 5-HT structures of substantia nigra. Changes of recall of passive avoidance conditioned reactions, and also painful stimulation aftereffects on locomotor activity of rats in "open field" were studied. It was shown that neurotoxin 5,7-DOT(More)
Comparative analysis of effects of neurotensin microinjections into caudate nucleus and substantia nigra on thirst-motivated motor conditioned reactions in rats, was performed. The microinjections facilitated extinction of conditioned reactions in response to negative stimuli and did not affect realization of responses to positive conditioned signals.(More)
This study addressed the effects of microinjections of neurotensin into the caudate nucleus and substantia nigra on the performance of motor reactions in response to positive and negative conditioned signals, as well as the post-effects of microinjections in subsequent experiments. Neurotensin had positive effects on the extinction of non-reinforced motor(More)
It was shown that neurotensin microinjections into the caudate nuclei facilitated of a conditioned reflex but not affected its realization. Besides, neurotensin was shown to have a positive aftereffect on extinction. Motor activity of rats in the "open field" was augmented after neurotensin administration. A conclusion was drawn that the functional effect(More)
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