A. S. Morozova

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Analgesic and secondary reinforcing effects of morphine, bremazocine and phencyclidine microinjections into ventral tegmental area were studied in rats. The drugs under study failed to affect nociceptive reactions produced by thermal, mechanic and electrical stimuli. Morphine and phencyclidine have shown reinforcing properties in place preference paradigm.(More)
A previous investigation demonstrated the role of the ventral tegmental region (VTR) in the realization of the reinforcing, but not the analgesic effect of opiates [2]. To continue the study of morphological and functional coupling of these two most important effects a further investigation was made of the antinociceptive and emotionally positive properties(More)
Comparative study of topographic and receptor selectivity of emotionally positive (place preference test) and analgetic (electrical and pressure nociceptive stimulation of the tail) effects of opioids was performed in rats. Morphine and selective agonists of mu-, kappa-, delta- and sigma-opiate receptors were administered through cannulae implanted into the(More)
Pain-relieving and reinforcing effects of morphine after microinjections into brain structures have been studied. Reinforcing effects were revealed after administration into n. accumbens, while analgesic--after injections into periventricular area of the midbrain and dorsomedial hypothalamus. Data obtained demonstrate neurotopographic heterogeneity of two(More)
The discovery of heterogeneity of the antinocieeptive and emotionally positive action of analgesics may serve as the basis for an oriented search for analgesics free from potential toxicomanic effects. Previously the writers obtained evidence of a difference in the analgesic and psychotropic effects of morphine in the course of development of tolerance and(More)
The action of L-tryptophan (25 mg/kg, intraperitoneally) and microinjection of serotonin (20 μg), dopamine (10 μg), and neostigmine (5 μg) into the circum aqueductal gray matter on the antinociceptive effect of stimulation of the same points of the mesencephalon was studied in rats with implanted cannula-electrodes. L-tryptophan, serotonin, and neostigmine(More)
In chronic experiments on rats it was established that electric stimulation of certain areas of the midbrain depresses pain reactions of different genesis. Morphine in subanalgetic doses (2--2.5 mg/kg) reveals and potentiates the antinociceptive effect of central stimulation shown first of all by depression of the complex highly integrated components of an(More)
In experiments on rats with implanted electrode-cannules there were studied the effects of L-tryptophane (25 mg/kg intraperitoneally) and microinjections of serotonin (20 micrograms), dopamine (10 micrograms) and proserine (5 micrograms) into the area of periaqueductal central gray on the antinociceptive effect caused by stimulation of the same "points" of(More)
It has been shown in rat experiments that repeated administration of morphine produces tolerance to the effect of stimulation analgesia (SA). In the control group, the same stimulation of the periaqueductal gray matter (PGM) failed to produce tolerance. Naloxone (2 mg/kg i.p.) exerted a partially antagonistic influence on SA in the control group and did not(More)
Components of complex emotional reaction to nociceptive stimulation as well as antinociceptive effect of periaqueductal gray matter (PAG) electrical stimulation were determined in rats. Animals were treated with morphine hydrochloride or saline for 10 days. Morphine analgesic effect during subchronic dosage (50 mg/kg a day) was gradually decreased. The same(More)
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