A S Marrazzi

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A representative psychotogen, lysergic acid diethylamide (LSD-25), in doses small enough to be devoid of gross effects, increases response latency in rats to a tone indicating the availability of water reward; this effect is greatly reduced by prophylactic administration of a representative phenothiazine tranquilizer, chlorpromazine (CPZ), in doses that per(More)
Extra- and intracellular recording of the cerebral cortical actions of close-arterially injected serotonin (5HT) and LSD in the cat shows them to be powerful synaptic inhibitors. They are specifically and differentially blocked by chlorpromazine (CPZ). The membrane parameters including spike generation, polarization, transmembrane conductance, and IPSPs(More)