A. S. Loginov

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Cycloheximide in sublethal doses caused apoptosis in liver cells in vivo, inducing c-myc, c-fos, c-jun and p53 genes and accumulation of sphingosine, a toxic product of the sphingomyelin cycle. These data support the hypothesis that continuous synthesis of labile protective proteins is required to restrain apoptosis in liver; sphingosine might be important(More)
AIM To estimate interleukines levels in chronic hepatitis (CH) in respect to CH etiological factor, activity and stage. MATERIAL AND METHODS Enzyme immunoassay (kits from proteinovy Kontur, St-Petersburg) determined levels of IL-1 beta, IL-4, IL-6 and TNF-alpha in the peripheral blood of 250 patients with chronic hepatitis C (CHC), B (CHB), D (CHD) and G(More)
The activity of adenylate cyclase in the hepatocyte plasma membranes, content of cAMP, and cAMP/cGMP ratio in the liver and blood plasma are decreased in patients with chronic liver diseases (fatty dystrophy, chronic hepatitis, and cirrhosis). This decrease depends on the disease severity and is most pronounced in cirrhosis. The sensitivity of liver(More)
Out of 15 patients with chronic pancreatitis (CP) treated with sandostatin, 8 patients demonstrated a complete and 6 partial response. One patient did not respond. Pain relief occurred in all of them. Side effects were registered in 3 patients (doughy stools 4 times a day throughout treatment). Normal blood levels of pancreatic enzymes, insulin secretion,(More)
Patients with stubborn peptic ulcers were exposed to copper vapor laser of various intensities with similar irradiation energy. The best therapeutic effect (more rapid ulcer healing) was achieved when ulcer bottom and edges were exposed to laser of higher intensity; the effect is explained by a higher stimulation of inflammation and a more rapid and(More)
Characteristics of optical recognition programs are described from the standpoint of typical recognition program modules. Not only quality criteria for the separate character recognition but also parameters of other important stages of document input, such as character boundary segmentation, binarization, page segmentation, and storing results, are(More)
Diagnostic methods for detecting forms and strains of Helicobacter pylori isolated from biopsy specimens of gastric mucosa in 28 patients with duodenal ulcers and evaluation of its eradication were compared. Biopsy specimens from all patients were tested for the presence of H. pylori by the urease test, histological method, and PCR with species-specific(More)
A decrease in activity of main enzymes responsible for inactivation of reactive intermediates of oxygen was found in patients with chronic impairments of liver tissue. In chronic active hepatitis superoxide dismutase and catalase activities were decreased, while more pronounced alterations in the enzymatic activity were observed in primary biliary(More)