A. S. Khalanskii

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Dependence of growth of a tumor on the degree of its blood supply is widely known and much attention has been devoted to the study of this problem in oncology. It has been shown that the fastest proliferating zones of a tumor usually coincide with areas of densest vascularization [1, 7, 14]. Spreading of tumor cells often takes place directly along the(More)
Extract from the brain of young mice produced weak cytoproliferative effect on cultured glial cells, while brain extract from old mice 3–4- and 30–60-fold stimulated glial proliferation in primary and passaged cell cultures, respectively.
Isoenzyme spectrum and total activity of arginase were studied in rat brain during growth of transplanted neurinoma and glioma as well as in malignant tissues of human brain. After transplantation of the tumors two peaks of arginase activation were observed within 2-4 days in rat brain tissues and within 16 days in tumoral tissue. Positively charged(More)
The expression of chordin P-epitope in dissociated cell culture of rat brain is studied by indirect immunofluorescence. Specific fluorescence is confined to compact bipolar and stellate cells on a layer of P-negative spread cells. Granular cells of the cerebellum, spinal neurons, neurons, and Schwann cells are P-negative. Double staining with monoclonal and(More)
Arginase is a cytostat ic enzyme, for by breaking down arginine it inhibits protein synthesis and dis turbs t ransi t ion of cel ls p repared for division f rom the Gj phase into the S phase of the mitotic cycle [1, 7]. Investigations have shown [5, 9] that growth of a cell culture is inhibited by arginase a~d activated by the addition of arginine. Activity(More)
A vascular system of several strains of brain tumors: neurinoma 46-1, gliomas: 11-9-2 and 101-8 were investigated by means of automatic analysis of microangiograms and histochemical-luminescent estimation of endothelial cells. It was shown that the mean quantity of vessels and their section-size in all strains of tumors are less than control independently(More)
The methods of quantitative immunoelectrophoresis and indirect immunofluorescence were used study the content of glial fibrillary acid protein in 10 serially reinoculated rat gliomas induced primarily by ethylnitrosourea (a total of 135 tumors). It was found that the GFAP content reduced with increase of malignancy. However, wide scattering of the GFAP(More)
The authors studied the content of lactic acid in glial tumors of the brain and brain tissue of rats in short-term artificial hyperglycemia. In short-term artificial glycemia the lactic acid content in glial tumors of animals was almost twice the level of this metabolite in the brain tissue, which is due to the high potential rate of glucose consumption by(More)