A. S. Kaplanskii

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Using methods of quantitative histomorphometry, the effect of 15- and 30-day exposure to antiorthostatic hypokinesia (-10 degrees) on spongy bone of iliac crests and proximal metaphysis of tibia of Macaca mulatta was examined. It was found that the exposure caused osteoporosis of bone spongiosa. Osteoporotic changes increased progressively with time of(More)
Using a semi-automatic image analyzer MOP Videoplan, a quantitative histomorphometric investigation of sponge bone of tibial metaphyses, iliac crests and lumbar vertebrae of monkeys kept for 14 days in the head-down position (at -10 degrees) was carried out. This exposure was found to cause spongy bone reduction in all the above bones. The lowered number(More)
Effects of graded support loads and stimulators of the central nervous system (ephedrine and strychnine) on growth of bones and the volume of spongy bone tissue in the proximal metaphyses of the shin bones were studied in the 14-day experiment with rats suspended by tail in the orthostatic position. It is indicated that the support loads in combination with(More)
Proximal metaphyses of tibial bones from the Sprague-Dowly rats exposed in US dedicated space life sciences laboratory SLS-2 for 13-14 days and sacrificed on day 13 in microgravity and within 5 hours and 14 days following recovery were the subject of histological, histochemical, and histomorphometric analyses. After the 13-day flight of SLS-2 the rats(More)
Two days before launch of the biosatellite Cosmos-2044 five rats were exposed to surgical intervention: their fibulas were cut bilaterally. The purpose was to study the effect of microgravity on bone fracture healing. Histologically and histomorphometrically it was demonstrated that healing was inhibited; as a result, bone callus was poorly developed and(More)
Morphofunctional changes in somatotrophs and gonadotrophs of the adenohypophysis and Leydig's cells in the testicles were investigated histologically and hystomorphometrically in male rats following microgravity or tail-suspension. Deficient loading of the musculoskeletal system in microgravity was shown to suppress the functional activity of somatotrophs,(More)
Preventive administration of vitamin D3 active metabolites 1.25(OH)2D3 and 24.25(OH)2D3 into growing rats, kept under conditions of long-term hard hypokinesia, normalized Ca metabolism and the state of bone tissue depending on the preparations dose and their combination. 1.25(OH)2D3 at a dose of 0.03 microgram per an animal daily augmented effectively the(More)
Immunohistochemistry and histomorphometry were employed to assay thyroid and parathyroid glands in hypophysectomized rats following a10-day tail suspension in head-down position and daily injection of either physiological solution or growth hormone or insulin-like growth factor 1 on the background of physical exercise, i.e. ascent up a 1 m high staircase(More)
The literature on the problem of stress-inducing effect of weightlessness is reviewed. On the basis of scrupulous analysis of the data accumulated in the rat flight experiments aboard the Cosmos biosatellites and the US Space Life Sciences Laboratory (SLS-2) it is concluded that although the ever-acting factor of space mission, microgravity does not cause(More)