A S Kaplanskiĭ

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Tibia and vertebrae of rats exposed to hypokinesia or head-down suspension were investigated by quantitative histomorphometry. It was found that 35- and 60-day hypokinesia as well as 35-day suspension caused osteoporosis in the tibial and vertebral spongiosa. The development of osteoporosis was accompanied by a significant reduction in the number of(More)
Summarized are the results of comparative analysis of morphological changes in rat's skeletal muscles after microgravity and its simulation. On completion of space flight, hindlimb muscles of rats exhibited atrophy developed in space microgravity in consequence of the lack of weight-bearing loads and changes solely in the slow anti-g muscles due to the(More)
Using a semi-automatic image analyzer MOP Videoplan, a quantitative histomorphometric investigation of sponge bone of tibial metaphyses, iliac crests and lumbar vertebrae of monkeys kept for 14 days in the head-down position (at -10 degrees) was carried out. This exposure was found to cause spongy bone reduction in all the above bones. The lowered number(More)
Using methods of quantitative histomorphometry, the effect of 15- and 30-day exposure to antiorthostatic hypokinesia (-10 degrees) on spongy bone of iliac crests and proximal metaphysis of tibia of Macaca mulatta was examined. It was found that the exposure caused osteoporosis of bone spongiosa. Osteoporotic changes increased progressively with time of(More)
Proximal metaphyses of tibial bones from the Sprague-Dowly rats exposed in US dedicated space life sciences laboratory SLS-2 for 13-14 days and sacrificed on day 13 in microgravity and within 5 hours and 14 days following recovery were the subject of histological, histochemical, and histomorphometric analyses. After the 13-day flight of SLS-2 the rats(More)
Two days before launch of the biosatellite Cosmos-2044 five rats were exposed to surgical intervention: their fibulas were cut bilaterally. The purpose was to study the effect of microgravity on bone fracture healing. Histologically and histomorphometrically it was demonstrated that healing was inhibited; as a result, bone callus was poorly developed and(More)
Morphofunctional changes in somatotrophs and gonadotrophs of the adenohypophysis and Leydig's cells in the testicles were investigated histologically and hystomorphometrically in male rats following microgravity or tail-suspension. Deficient loading of the musculoskeletal system in microgravity was shown to suppress the functional activity of somatotrophs,(More)
Preventive administration of vitamin D3 active metabolites 1.25(OH)2D3 and 24.25(OH)2D3 into growing rats, kept under conditions of long-term hard hypokinesia, normalized Ca metabolism and the state of bone tissue depending on the preparations dose and their combination. 1.25(OH)2D3 at a dose of 0.03 microgram per an animal daily augmented effectively the(More)
The article includes excerpts from The Bioethic Rules of Research With Humans and Animals that have established on analysis of national and international bioethic guidelines for biomedical research with the use of humans and animals and are a part of the ISS human use guidelines.
Bones of the rats flown on Cosmos-1667 were examined histologically and histomorphometrically. It was found that 7-day exposure to weightlessness led to osteoporosis in the spongy matter of proximal metaphyses of tibia and, although to a lesser extent, in the spongiosa of lumbar vertebrae whereas no signs of osteoporosis were seen in the spongy matter of(More)